Cardiovascular functions of central corticotropin-releasing factor related peptides system.
Neuropeptides
; 75: 18-24, 2019 Jun.
Article
en En
| MEDLINE
| ID: mdl-30922523
The corticotropin-releasing factor (CRF) related peptides system has widespread distributions in central nervous system, to perform many physiological and pathophysiological functions, including cardiovascular functions. A complex connection exists between the central CRF related peptides system and cardiovascular system. There are multiple pathways and mechanisms through which the central CRF related peptides system influences cardiovascular functions. A dysfunction in the central CRF related peptides system may lead to a wide range of alterations in cardiovascular functions. Though there are difficulties or limitations in establishing exact modulatory roles of the central CRF related peptides system in cardiovascular functions. The central CRF related peptides system as target to prevent cardiovascular diseases is being pursued with increasing interest. In this review, we summarize recent understanding on cardiovascular functions of the CRF related peptides system in limbic forebrain, hypothalamus and brain stem structures, discuss mechanisms of the central CRF related peptides system in control of cardiovascular functions, and suggest that the central CRF related peptides system may be a potent candidate for prevention of cardiovascular diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Corticotropina
/
Sistema Cardiovascular
/
Receptores de Hormona Liberadora de Corticotropina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neuropeptides
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Países Bajos