Your browser doesn't support javascript.
loading
Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth.
Shurin, Galina V; Kruglov, Oleg; Ding, Fei; Lin, Yan; Hao, Xingxing; Keskinov, Anton A; You, Zhaoyang; Lokshin, Anna E; LaFramboise, William A; Falo, Louis D; Shurin, Michael R; Bunimovich, Yuri L.
Afiliación
  • Shurin GV; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Kruglov O; Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Ding F; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Lin Y; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Hao X; Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Keskinov AA; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • You Z; Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Lokshin AE; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • LaFramboise WA; Hillman Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Falo LD; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Shurin MR; Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
  • Bunimovich YL; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Cancer Res ; 79(10): 2736-2747, 2019 05 15.
Article en En | MEDLINE | ID: mdl-30914431
The tumor microenvironment has been compared with a nonhealing wound involving a complex interaction between multiple cell types. Schwann cells, the key regulators of peripheral nerve repair, have recently been shown to directly affect nonneural wound healing. Their role in cancer progression, however, has been largely limited to neuropathic pain and perineural invasion. In this study, we showed that melanoma activated otherwise dormant functions of Schwann cells aimed at nerve regeneration and wound healing. Such reprogramming of Schwann cells into repair-like cells occurred during the destruction and displacement of neurons as the tumor expanded and via direct signaling from melanoma cells to Schwann cells, resulting in activation of the nerve injury response. Melanoma-activated Schwann cells significantly altered the microenvironment through their modulation of the immune system and the extracellular matrix in a way that promoted melanoma growth in vitro and in vivo. Local inhibition of Schwann cell activity following cutaneous sensory nerve transection in melanoma orthotopic models significantly decreased the rate of tumor growth. Tumor-associated Schwann cells, therefore, can have a significant protumorigenic effect and may present a novel target for cancer therapy. SIGNIFICANCE: These findings reveal a role of the nerve injury response, particularly through functions of activated Schwann cells, in promoting melanoma growth.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Schwann / Transducción de Señal / Proliferación Celular / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cancer Res Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Schwann / Transducción de Señal / Proliferación Celular / Melanoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cancer Res Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos