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Comparison of nylon-flocked swab and Dacron swab cytology for anal HSIL detection in transgender women and gay, bisexual, and other men who have sex with men.
Wiley, Dorothy J; Hsu, Hilary K; Ganser, Martha A; Brook, Jenny; Elashoff, David A; Moran, Matthew G; Young, Stephen A; Joste, Nancy E; Mitsuyasu, Ronald; Darragh, Teresa M; Morris, David H; Martínez-Maza, Otoniel M; Detels, Roger; Rao, Jian Yu; Bolan, Robert K; Shigeno, Eric T; Rodriguez, Ernesto.
Afiliación
  • Wiley DJ; School of Nursing, University of California Los Angeles, Los Angeles, California.
  • Hsu HK; School of Nursing, University of California Los Angeles, Los Angeles, California.
  • Ganser MA; School of Nursing, University of California Los Angeles, Los Angeles, California.
  • Brook J; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
  • Elashoff DA; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
  • Moran MG; School of Nursing, University of California Los Angeles, Los Angeles, California.
  • Young SA; Desert AIDS Project, Palm Springs, California.
  • Joste NE; Tricore Reference Laboratories, University of New Mexico, Albuquerque, New Mexico.
  • Mitsuyasu R; Tricore Reference Laboratories, University of New Mexico, Albuquerque, New Mexico.
  • Darragh TM; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
  • Morris DH; Department of Pathology, University of California San Francisco, San Francisco, California.
  • Martínez-Maza OM; Desert AIDS Project, Palm Springs, California.
  • Detels R; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
  • Rao JY; Jonathan and Karen Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.
  • Bolan RK; Jonathan and Karen Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.
  • Shigeno ET; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
  • Rodriguez E; Los Angeles LGBT Center, Los Angeles, California.
Cancer Cytopathol ; 127(4): 247-257, 2019 04.
Article en En | MEDLINE | ID: mdl-30913381
BACKGROUND: An anal histological high-grade squamous intraepithelial lesion (hHSIL) is an anal cancer precursor. Experts recommend Dacron swab anal cytology as a primary screen for anal hHSILs, especially among human immunodeficiency virus-infected and -uninfected men who have sex with men (MSM). Studies have shown that Dacron cytology inaccurately predicts anal hHSILs and results in unnecessary diagnostic procedures. Nylon-flocked (NF) swabs have been shown to trap pathogens and cells well. Thus, this study compared test characteristics of anal cytology using NF and Dacron swab collection protocols to predict anal hHSILs. METHODS: A single-visit, randomized clinical trial compared NF and Dacron swab anal cytology specimens to predict high-resolution anoscopy and biopsy-diagnosed anal hHSILs. Data for 326 gay men, bisexual men, other MSM, and male-to-female transgender women contributed descriptive and tabular statistics with which unadjusted and fully adjusted logistic regression models were constructed. The models estimated the odds of hHSILs, test accuracy (area under the curve [AUC]) and sensitivity, and specificity as well as the positive and negative predictive values of abnormal NF and Dacron cytology for predicting hHSILs. RESULTS: In the fully adjusted model, the sensitivities for NF and Dacron cytology were nearly equal (48% vs 47%), but the specificity was higher with NF cytology (76% vs 69%). Comparisons of the areas under receiver operating characteristic curves showed that NF cytology alone predicted hHSILs better than the covariate model (AUC, 0.69 vs 0.63; P = .02), but NF and Dacron cytology comparisons showed no statistically significant differences (AUC, 0.69 vs 0.67; P = .3). CONCLUSIONS: NF cytology and Dacron cytology provide modest sensitivity, but NF cytology has higher specificity and accuracy, and this is important for lowering the costs of population-based screening.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Ano / Manejo de Especímenes / Homosexualidad Masculina / Citodiagnóstico / Personas Transgénero / Lesiones Intraepiteliales Escamosas Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Cytopathol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Ano / Manejo de Especímenes / Homosexualidad Masculina / Citodiagnóstico / Personas Transgénero / Lesiones Intraepiteliales Escamosas Tipo de estudio: Clinical_trials / Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Cytopathol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos