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Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease.
Wadhwa, Ridhima; Aggarwal, Taru; Malyla, Vamshikrishna; Kumar, Nitesh; Gupta, Gaurav; Chellappan, Dinesh Kumar; Dureja, Harish; Mehta, Meenu; Satija, Saurabh; Gulati, Monica; Maurya, Pawan Kumar; Collet, Trudi; Hansbro, Philip Michael; Dua, Kamal.
Afiliación
  • Wadhwa R; Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, India.
  • Aggarwal T; Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.
  • Malyla V; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, New South Wales, Australia.
  • Kumar N; Centre for Inflammation, Centenary Institute, Sydney, New South Wales, Australia.
  • Gupta G; Amity Institute for Advanced Research & Studies (M&D), Amity University, Noida, Uttar Pradesh, India.
  • Chellappan DK; School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan, India.
  • Dureja H; Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
  • Mehta M; Department of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak, Haryana, India.
  • Satija S; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Gulati M; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Maurya PK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Collet T; Department of Biochemistry, Central University of Haryana, Mahendergarh, Haryana, India.
  • Hansbro PM; Innovative Medicines Group, Institute of Health & Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
  • Dua K; Priority Research Centre for Healthy Lungs, University of Newcastle & Hunter Medical Research Institute, Newcastle, New South Wales, Australia.
J Cell Physiol ; 234(10): 16703-16723, 2019 08.
Article en En | MEDLINE | ID: mdl-30912142
Chronic obstructive pulmonary disease accounts as the leading cause of mortality worldwide prominently affected by genetic and environmental factors. The disease is characterized by persistent coughing, breathlessness airways inflammation followed by a decrease in forced expiratory volume1 and exacerbations, which affect the quality of life. Determination of genetic, epigenetic, and oxidant biomarkers to evaluate the progression of disease has proved complicated and challenging. Approaches including exome sequencing, genome-wide association studies, linkage studies, and inheritance and segregation studies played a crucial role in the identification of genes, their pathways and variation in genes. This review highlights multiple approaches for biomarker and gene identification, which can be used for differential diagnosis along with the genome editing tools to study genes associated with the development of disease and models their function. Further, we have discussed the approaches to rectify the abnormal gene functioning of respiratory tissues and various novel gene editing techniques like Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), and clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Cell Physiol Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Genética / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Diagnostic_studies / Prognostic_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Cell Physiol Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos