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Biochemical, Histopathologic, and Genotoxic Effects of Ethanol Extract of Salvia hypargeia (Fisch. & Mey.) on Incisional and Excisional Wounded Diabetic Rats.
Ozay, Yusuf; Guzel, Sevda; Gokalp Ozkorkmaz, Ebru; Kumas, Meltem; Uzun, Cosar; Yildirim, Zuhal; Celik, Ayla; Camlica, Yusuf; Yumrutas, Onder; Guler, Gizem; Erdal, Nurten; Tasdelen, Bahar; Didem Celikcan, Havva; Kahraman, Ahmet.
Afiliación
  • Ozay Y; Department of Medical Biology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
  • Guzel S; Department of Pharmacognosy, Faculty of Pharmacy, Mersin University, Mersin, Turkey.
  • Gokalp Ozkorkmaz E; Department of Histology and Embryology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
  • Kumas M; Department of Histology, Faculty of Medicine, Bezmi Alem Vakif University, Istanbul, Turkey.
  • Uzun C; Department of Biophysics, Faculty of Medicine, Mersin University, Mersin, Turkey.
  • Yildirim Z; Etimesgut Public Health Laboratory, Ankara, Turkey.
  • Celik A; Department of Biology, Faculty of Science, Mersin University, Mersin, Turkey.
  • Camlica Y; Department of Biology, Faculty of Science, Mersin University, Mersin, Turkey.
  • Yumrutas O; Department of Medical Biology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey.
  • Guler G; Department of Biology, Faculty of Science, Mersin University, Mersin, Turkey.
  • Erdal N; Department of Biophysics, Faculty of Medicine, Mersin University, Mersin, Turkey.
  • Tasdelen B; Department of Biostatistics and Medical Informatics, Faculty of Medicine, Mersin University, Mersin, Turkey.
  • Didem Celikcan H; Department of Biostatistics and Medical Informatics, Faculty of Medicine, Mersin University, Mersin, Turkey.
  • Kahraman A; Department of Biology, Faculty of Arts and Science, Usak University, Usak, Turkey.
J Invest Surg ; 34(1): 7-19, 2021 Jan.
Article en En | MEDLINE | ID: mdl-30909758
Purpose: Nonhealing wounds are a serious problem of diabetic patients. Salvia species are traditionally used for the treatment of wounds. The aim of the study was to investigate the effects of ointment prepared with ethanol extract obtained from the aerial parts of Salvia hypargeia, an endemic plant from Turkey, on diabetic rat incisional and excisional skin wounds. Materials and Methods: Male Wistar albino rats (n: 60) were divided into five groups. Diabetes was induced and two concentrations (0.5% and 1%) of the extract were used for ointments and applied on wounds for 7 and 14 days. Fito cream was chosen as a reference drug. Results: In excisional wounds, healing ratios of 0.5% (63.4% and 99.3%) and 1% (65.5% and 99.9%) S. hypargeia groups were higher compared to control (35.9% and 75.1%), and in incisional wounds, healing ratios of 0.5% (78.1% and 98.5%) and 1% (84.4% and 99.4%) S. hypargeia groups were higher compared to control (30.5% and 72.9%) (p < .01). Hydroxyproline (0.31 ± 0.3 and 0.34 ± 0.2) levels were lower and GSH (10.7 ± 3.1 and 7.6 ± 0.9) levels were higher in 0.5% and 1% S. hypargeia groups on the 14th day (p < .01). Histopathological results revealed re-epithelialization and formation of granulation tissue in all S. hypargeia groups. Genotoxicologic results indicated, GDI, DCP values, and MN frequency of 0.5% and 1% S. hypargeia groups did not reach to significant levels both on the 7 and 14 days. Conclusions: S. hypargeia may have a potential for therapeutic use in treatment and management of diabetic wounds with a successful topical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salvia / Diabetes Mellitus Experimental Límite: Animals / Humans / Male Idioma: En Revista: J Invest Surg Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salvia / Diabetes Mellitus Experimental Límite: Animals / Humans / Male Idioma: En Revista: J Invest Surg Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Estados Unidos