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Expression of LRP1 and CHOP genes associated with peripheral neuropathy in type 2 diabetes mellitus: Correlations with nerve conduction studies.
El-Horany, Hemat El-Sayed; Watany, Mona Mohamed; Hagag, Rasha Youssef; El-Attar, Shimaa Hassan; Basiouny, Mohamed Abdelaziz.
Afiliación
  • El-Horany HE; Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta 31527, Egypt. Electronic address: hemat.elhorany@med.tanta.edu.eg.
  • Watany MM; Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Hagag RY; Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • El-Attar SH; Internal Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
  • Basiouny MA; MD Neurology, Neuropsychiatry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Gene ; 702: 114-122, 2019 Jun 20.
Article en En | MEDLINE | ID: mdl-30902789
AIM: Diabetic peripheral neuropathy (DPN) is a frequent and debilitating complication of diabetes mellitus. The low-density lipoprotein receptor-related protein-1 (LRP-1) is a multifunctional cell surface receptor playing critical roles in lipoprotein metabolism and several cell signaling processes. C/EBP homologous protein (CHOP) is a main conduit to endoplasmic reticulum stress-induced apoptosis. We aimed to investigate LRP1 and CHOP gene expression in peripheral blood cells of type 2 diabetes mellitus (T2DM) subjects to clarify its possible relation to DPN pathogenesis. METHOD: The study included 20 non-complicated T2DM subjects, 20 subjects with DPN and 20 healthy controls. Quantitative real time PCR was used to study gene expression. RESULTS: There was a significant reduction in LRP1 mRNA expression and a significant increase in CHOP mRNA expression in subjects with DPN compared to non-complicated group and healthy controls. Both LRP1 and CHOP expression levels were inversely correlated, and both showed significant correlation with HbA1c, hyperlipidemia, hs-CRP, and different electrophysiological parameters. Receiver operating characteristics (ROC) analysis suggested that both LRP1 and CHOP mRNA expression and hs-CRP levels had great potential advantages to predict the progression of DPN. CONCLUSION: LRP1 and CHOP might be involved in DPN pathogenesis and progression, thus providing opportunities for early detection and treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad / Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas / Factor de Transcripción CHOP Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Gene Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad / Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas / Factor de Transcripción CHOP Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Gene Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos