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Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering.
Buckley, Conor T; Hoyland, Judith A; Fujii, Kengo; Pandit, Abhay; Iatridis, James C; Grad, Sibylle.
Afiliación
  • Buckley CT; Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute Trinity College Dublin, The University of Dublin Dublin Ireland.
  • Hoyland JA; School of Engineering, Trinity College Dublin The University of Dublin Dublin Ireland.
  • Fujii K; Advanced Materials and Bioengineering Research (AMBER) Centre Royal College of Surgeons in Ireland & Trinity College Dublin, The University of Dublin Dublin Ireland.
  • Pandit A; Division of Cell Matrix Biology and Regenerative Medicine University of Manchester Manchester UK.
  • Iatridis JC; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust Manchester Academic Health Science Centre Manchester UK.
  • Grad S; Leni & Peter W. May Department of Orthopaedics Icahn School of Medicine at Mount Sinai New York New York USA.
JOR Spine ; 1(3): e1029, 2018 Sep.
Article en En | MEDLINE | ID: mdl-30895276
Low back pain represents the highest burden of musculoskeletal diseases worldwide and intervertebral disc degeneration is frequently associated with this painful condition. Even though it remains challenging to clearly recognize generators of discogenic pain, tissue regeneration has been accepted as an effective treatment option with significant potential. Tissue engineering and regenerative medicine offer a plethora of exploratory pathways for functional repair or prevention of tissue breakdown. However, the intervertebral disc has extraordinary biological and mechanical demands that must be met to assure sustained success. This concise perspective review highlights the role of the disc microenvironment, mechanical and clinical design considerations, function vs mimicry in biomaterial-based and cell engineering strategies, and potential constraints for clinical translation of regenerative therapies for the intervertebral disc.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JOR Spine Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JOR Spine Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos