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Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion.
Elliott, Irmina A; Dann, Amanda M; Xu, Shili; Kim, Stephanie S; Abt, Evan R; Kim, Woosuk; Poddar, Soumya; Moore, Alexandra; Zhou, Lei; Williams, Jennifer L; Capri, Joseph R; Ghukasyan, Razmik; Matsumura, Cynthia; Tucker, D Andrew; Armstrong, Wesley R; Cabebe, Anthony E; Wu, Nanping; Li, Luyi; Le, Thuc M; Radu, Caius G; Donahue, Timothy R.
Afiliación
  • Elliott IA; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Dann AM; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Xu S; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Kim SS; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
  • Abt ER; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095.
  • Kim W; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Poddar S; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
  • Moore A; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095.
  • Zhou L; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
  • Williams JL; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095.
  • Capri JR; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
  • Ghukasyan R; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095.
  • Matsumura C; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Tucker DA; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Armstrong WR; Department of Pancreatic and Thyroidal Surgery, Shengjing Hospital, China Medical University, Shenyang 110003, China.
  • Cabebe AE; Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA 90502.
  • Wu N; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.
  • Li L; Ahmanson Translational Imaging Division, University of California, Los Angeles, CA 90095.
  • Le TM; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Radu CG; Department of Surgery, University of California, Los Angeles, CA 90095.
  • Donahue TR; Department of Surgery, University of California, Los Angeles, CA 90095.
Proc Natl Acad Sci U S A ; 116(14): 6842-6847, 2019 04 02.
Article en En | MEDLINE | ID: mdl-30894490
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Cloroquina / Ácido Aspártico / Carcinoma Ductal Pancreático / Lisosomas / Mitocondrias Límite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Cloroquina / Ácido Aspártico / Carcinoma Ductal Pancreático / Lisosomas / Mitocondrias Límite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos