8-Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis.

Odingo, Joshua O; Early, Julie V; Smith, Jake; Johnson, James; Bailey, Mai A; Files, Megan; Guzman, Junitta; Ollinger, Juliane; Korkegian, Aaron; Kumar, Anuradha; Ovechkina, Yulia; Parish, Tanya

Odingo, Joshua O; Early, Julie V; Smith, Jake; Johnson, James; Bailey, Mai A; Files, Megan; Guzman, Junitta; Ollinger, Juliane; Korkegian, Aaron; Kumar, Anuradha; Ovechkina, Yulia; Parish, Tanya.

Afiliación

Odingo JO; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Early JV; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Smith J; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Johnson J; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Bailey MA; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Files M; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Guzman J; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Ollinger J; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Korkegian A; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Kumar A; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Ovechkina Y; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.
Parish T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington.

Drug Dev Res ; 80(5): 566-572, 2019 08.

Article en En | MEDLINE | ID: mdl-30893501

Asunto(s)

Antituberculosos/síntesis química; Hidroxiquinolinas/síntesis química; Mycobacterium tuberculosis/crecimiento & desarrollo; Oxiquinolina/análogos & derivados; Animales; Antituberculosos/química; Antituberculosos/farmacología; Chlorocebus aethiops; Células Hep G2; Humanos; Hidroxiquinolinas/química; Hidroxiquinolinas/farmacología; Pruebas de Sensibilidad Microbiana; Viabilidad Microbiana/efectos de los fármacos; Estructura Molecular; Mycobacterium tuberculosis/efectos de los fármacos; Relación Estructura-Actividad; Células Vero

Palabras clave

Mycobacterium tuberculosis; tuberculosis; antibacterial; hydroxyquinoline; structure-activity relationship

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxiquinolina / Hidroxiquinolinas / Mycobacterium tuberculosis / Antituberculosos Límite: Animals / Humans Idioma: En Revista: Drug Dev Res Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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