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CITED2 mediates the mechanical loading-induced suppression of adipokines in the infrapatellar fat pad.
Liu, Lidi; He, Zhiyong; Xu, Lin; Lu, Laijin; Feng, Haotian; Leong, Daniel J; Kim, Sun J; Hirsh, David M; Majeska, Robert J; Goldring, Mary B; Cobelli, Neil J; Sun, Hui B.
Afiliación
  • Liu L; Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.
  • He Z; Department of Spine Surgery, Jilin Provincial Key Laboratory of Tissue Repair, Reconstruction and Regeneration, The First Hospital of Jilin University, Jilin, China.
  • Xu L; Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.
  • Lu L; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York.
  • Feng H; Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.
  • Leong DJ; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York.
  • Kim SJ; Department of Hand Surgery, Jilin Provincial Key Laboratory of Tissue Repair, Reconstruction and Regeneration, The First Hospital of Jilin University, Jilin, China.
  • Hirsh DM; Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.
  • Majeska RJ; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York.
  • Goldring MB; Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.
  • Cobelli NJ; Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York.
  • Sun HB; Department of Orthopaedic Surgery, Albert Einstein College of Medicine, Bronx, New York.
Ann N Y Acad Sci ; 1442(1): 153-164, 2019 04.
Article en En | MEDLINE | ID: mdl-30891782
Adipokines secreted from the infrapatellar fat pad (IPFP), such as adipsin and adiponectin, have been implicated in osteoarthritis pathogenesis. CITED2, a mechanosensitive transcriptional regulator with chondroprotective activity, may modulate their expression. Cited2 haploinsufficient mice (Cited2+/- ) on a high-fat diet (HFD) exhibited increased body weight and increased IPFP area compared to wild-type (WT) mice on an HFD. While an exercise regimen of moderate treadmill running induced the expression of CITED2, as well as PGC-1α, and reduced the expression of adipsin and adiponectin in the IPFP of WT mice on an HFD, Cited2 haploinsufficiency abolished the loading-induced expression of PGC-1α and loading-induced suppression of adipsin and adiponectin. Furthermore, knocking down or knocking out CITED2 in adipose stem cells (ASCs)/preadipocytes derived from the IPFP in vitro led to the increased expression of adipsin and adiponectin and reduced PGC-1α, and abolished the loading-induced suppression of adipsin and adiponectin and loading-induced expression of PGC-1α. Overexpression of PGC-1α in these ASC/preadipocytes reversed the effects caused by CITED2 deficiency. The current data suggest that CITED2 is a critical regulator in physiologic loading-induced chondroprotection in the context of an HFD and PGC-1α is required for the inhibitory effects of CITED2 on the expression of adipokines such as adipsin and adiponectin in the IPFP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rótula / Proteínas Represoras / Estrés Mecánico / Transactivadores / Tejido Adiposo / Adipoquinas Límite: Animals Idioma: En Revista: Ann N Y Acad Sci Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rótula / Proteínas Represoras / Estrés Mecánico / Transactivadores / Tejido Adiposo / Adipoquinas Límite: Animals Idioma: En Revista: Ann N Y Acad Sci Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos