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Effects of the fenugreek extracts on high-fat diet-fed and streptozotocin-induced type 2 diabetic mice.
Li, Xiao-Yan; Lu, Shuang-Shuang; Wang, Hong-Lun; Li, Gang; He, Yan-Feng; Liu, Xiao-Yu; Rong, Rong; Li, Ji; Lu, Xuan-Cheng.
Afiliación
  • Li XY; Laboratory Animal Center Chinese Center for Diseases Control and Prevention Beijing China.
  • Lu SS; Laboratory Animal Center Chinese Center for Diseases Control and Prevention Beijing China.
  • Wang HL; The State Key Laboratory of Plateau Ecology and Agriculture Qinghai University Xining China.
  • Li G; The Center for Mitochondria and Healthy Aging College of Life Sciences Yantai University Yantai China.
  • He YF; The College of Pharmacy Qinghai Nationalities University Xining China.
  • Liu XY; Laboratory Animal Center Chinese Center for Diseases Control and Prevention Beijing China.
  • Rong R; Laboratory Animal Center Chinese Center for Diseases Control and Prevention Beijing China.
  • Li J; The Center for Mitochondria and Healthy Aging College of Life Sciences Yantai University Yantai China.
  • Lu XC; Laboratory Animal Center Chinese Center for Diseases Control and Prevention Beijing China.
Animal Model Exp Med ; 1(1): 68-73, 2018 Mar.
Article en En | MEDLINE | ID: mdl-30891549
BACKGROUND: To study the antidiabetic effects and mechanisms of the fenugreek extracts in streptozotocin (STZ)-induced type 2 diabetic (T2DM) mice fed a high-fat diet (HFD). METHODS: We established C57BL/6J mice model of T2DM using HFD-fed and STZ-induced method. Then, the mice were administered with two types of fenugreek extracts (E1, flavonoid and E2, stilbene glycoside) for 4 weeks and the effects on fasting blood glucose (FBG), weight, superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and pathological indexes were investigated. RESULTS: Administration of fenugreek extracts decreased the FBG level compared with that of the model group. Comparatively, the high-dose E2 decreased the FBG more significantly than the other treatments did. Both extracts showed an obvious antioxidant effect by increasing serum SOD and CAT activities and decreasing the MDA content. Furthermore, the high-dose E1 showed a significant difference (P < .01) compared with the model group in the three investigated indexes. CONCLUSION: Our study demonstrated that both the flavonoid and stilbene glycoside extracts of fenugreek improved the hyperglycemia in the T2DM mice model. Moreover, the antidiabetic effects of both extracts might be due to their antioxidant activity in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Animal Model Exp Med Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Animal Model Exp Med Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos