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H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.
Harutyunyan, Ashot S; Krug, Brian; Chen, Haifen; Papillon-Cavanagh, Simon; Zeinieh, Michele; De Jay, Nicolas; Deshmukh, Shriya; Chen, Carol C L; Belle, Jad; Mikael, Leonie G; Marchione, Dylan M; Li, Rui; Nikbakht, Hamid; Hu, Bo; Cagnone, Gael; Cheung, Warren A; Mohammadnia, Abdulshakour; Bechet, Denise; Faury, Damien; McConechy, Melissa K; Pathania, Manav; Jain, Siddhant U; Ellezam, Benjamin; Weil, Alexander G; Montpetit, Alexandre; Salomoni, Paolo; Pastinen, Tomi; Lu, Chao; Lewis, Peter W; Garcia, Benjamin A; Kleinman, Claudia L; Jabado, Nada; Majewski, Jacek.
Afiliación
  • Harutyunyan AS; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Krug B; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Chen H; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Papillon-Cavanagh S; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Zeinieh M; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • De Jay N; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Deshmukh S; Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, H3T 1E2, Canada.
  • Chen CCL; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Belle J; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Mikael LG; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Marchione DM; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Center, Montreal, QC, H4A 3J1, Canada.
  • Li R; Department of Biochemistry and Biophysics, and Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Nikbakht H; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Hu B; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Cagnone G; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Cheung WA; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Mohammadnia A; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Bechet D; Center for Pediatric Genomic Medicine, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.
  • Faury D; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • McConechy MK; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Pathania M; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Jain SU; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Ellezam B; Samantha Dickson Brain Cancer Unit, University College London Cancer Institute, London, WCE1 6DD, United Kingdom.
  • Weil AG; Department of Biomolecular Chemistry, School of Medicine and Public Health and Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI, 53715, USA.
  • Montpetit A; Department of Pathology, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC, H3T 1C5, Canada.
  • Salomoni P; Department of Pediatric Neurosurgery, Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, QC, H3T 1C5, Canada.
  • Pastinen T; McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada.
  • Lu C; Samantha Dickson Brain Cancer Unit, University College London Cancer Institute, London, WCE1 6DD, United Kingdom.
  • Lewis PW; Nuclear Function in CNS pathophysiology, German Center for Neurodegenerative Diseases, 53127, Bonn, Germany.
  • Garcia BA; Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.
  • Kleinman CL; Center for Pediatric Genomic Medicine, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.
  • Jabado N; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY, 10032, USA.
  • Majewski J; Department of Biomolecular Chemistry, School of Medicine and Public Health and Wisconsin Institute for Discovery, University of Wisconsin, Madison, WI, 53715, USA.
Nat Commun ; 10(1): 1262, 2019 03 19.
Article en En | MEDLINE | ID: mdl-30890717
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Cromatina / Histonas / Glioblastoma / Complejo Represivo Polycomb 2 Tipo de estudio: Prognostic_studies Límite: Adolescent / Aged / Animals / Child / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Cromatina / Histonas / Glioblastoma / Complejo Represivo Polycomb 2 Tipo de estudio: Prognostic_studies Límite: Adolescent / Aged / Animals / Child / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido