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Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors.
Foppiani, Elisabetta Manuela; Candini, Olivia; Mastrolia, Ilenia; Murgia, Alba; Grisendi, Giulia; Samarelli, Anna Valeria; Boscaini, Giulia; Pacchioni, Lucrezia; Pinelli, Massimo; De Santis, Giorgio; Horwitz, Edwin M; Veronesi, Elena; Dominici, Massimo.
Afiliación
  • Foppiani EM; Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
  • Candini O; Rigenerand srl, Modena, Medolla, Italy.
  • Mastrolia I; Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
  • Murgia A; Rigenerand srl, Modena, Medolla, Italy.
  • Grisendi G; Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
  • Samarelli AV; Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
  • Boscaini G; Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
  • Pacchioni L; Rigenerand srl, Modena, Medolla, Italy.
  • Pinelli M; Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
  • De Santis G; Division of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Modena, Italy.
  • Horwitz EM; Division of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Modena, Italy.
  • Veronesi E; Division of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Modena, Italy.
  • Dominici M; Division of Plastic Surgery, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Modena, Italy.
Stem Cell Res Ther ; 10(1): 101, 2019 03 19.
Article en En | MEDLINE | ID: mdl-30890185
BACKGROUND: The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing number of clinical trials, it is still desirable to identify molecular markers that may help improve their performance both in vitro and after transplantation. METHODS: Recently, HOXB7 was identified as a master player driving the proliferation and differentiation of bone marrow mesenchymal progenitors. In this study, we investigated the effect of HOXB7 overexpression on the ex vivo features of adipose mesenchymal progenitors (AD-MSC). RESULTS: HOXB7 increased AD-MSC proliferation potential, reduced senescence, and improved chondrogenesis together with a significant increase of basic fibroblast growth factor (bFGF) secretion. CONCLUSION: While further investigations and in vivo models shall be applied for better understanding, these data suggest that modulation of HOXB7 may be a strategy for innovative tissue regeneration applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Tejido Adiposo / Regulación de la Expresión Génica / Proteínas de Homeodominio / Condrogénesis / Proliferación Celular / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Stem Cell Res Ther Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Tejido Adiposo / Regulación de la Expresión Génica / Proteínas de Homeodominio / Condrogénesis / Proliferación Celular / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Stem Cell Res Ther Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido