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Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods.
Mjelle, Anders B; Mulabecirovic, Anesa; Havre, Roald F; Rosendahl, Karen; Juliusson, Petur B; Olafsdottir, Edda; Gilja, Odd H; Vesterhus, Mette.
Afiliación
  • Mjelle AB; Department of Pediatric and Adolescent Medicine, Haukeland University Hospital.
  • Mulabecirovic A; Department of Clinical Medicine, University of Bergen.
  • Havre RF; National Centre for Ultrasound in Gastroenterology.
  • Rosendahl K; Department of Clinical Medicine, University of Bergen.
  • Juliusson PB; National Centre for Ultrasound in Gastroenterology.
  • Olafsdottir E; National Centre for Ultrasound in Gastroenterology.
  • Gilja OH; Department of Clinical Medicine, University of Bergen.
  • Vesterhus M; Department of Radiology, Section of Pediatric Radiology, Haukeland University Hospital.
J Pediatr Gastroenterol Nutr ; 68(5): 706-712, 2019 05.
Article en En | MEDLINE | ID: mdl-30889132
OBJECTIVES: Noninvasive tests for the evaluation of liver fibrosis are particularly helpful in children to avoid general anesthesia and potential complications of invasive tests. We aimed to establish reference values for 2 different elastography methods in a head-to-head comparison for children and adolescents 4 to 17 years, using transient elastography as common reference in a subset. METHODS: A total of 243 healthy participants aged 4 to 17 years were examined by a single observer with a full liver B-mode scan before elastography, following a minimum of 3 hours fasting. Liver stiffness measurements (LSMs) using 2-dimensional shear wave elastography (2D-SWE, GE Logiq E9) and point shear wave elastography (pSWE, Samsung RS80A with Prestige) were performed in all participants, and compared to transient elastography (TE, FibroScan) in a subset (n = 87). Interobserver agreement was evaluated in 50 children aged 4 to 17 years. RESULTS: Valid measurements were obtained in 242 of 243 (99.6%) subjects for 2D-SWE, 238 of 243 (97.9%) for pSWE, and in 83 of 87 (95.4%) for TE. Median liver stiffness overall was 3.3 (interquartile range [IQR] 2.7-4.3), 4.1 (IQR 3.6-4.7), and 4.1 kPa (IQR 3.5-4.6) for 2D-SWE, pSWE, and TE, respectively. Intraclass correlation coefficients between observers were 0.84 and 0.83 for 2D-SWE and pSWE, respectively. LSM values were significantly lower for 2D-SWE compared to pSWE and TE, and increased with advancing age. Higher LSM values in males were observed in adolescents. CONCLUSIONS: All methods showed excellent feasibility. 2D-SWE showed significantly lower LSM values than pSWE and TE, and lower failure rate compared to TE. Our results further indicate an age and sex effect on LSM values.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico por Imagen de Elasticidad / Hígado Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diagnóstico por Imagen de Elasticidad / Hígado Tipo de estudio: Diagnostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos