Your browser doesn't support javascript.
loading
The First Evidence of Cryptosporidium meleagridis Infection in a Colon Adenocarcinoma From an Immunocompetent Patient.
Kopacz, Zaneta; Kvác, Martin; Karpinski, Pawel; Hendrich, Andrzej B; Sasiadek, Maria M; Leszczynski, Przemyslaw; Sak, Bohumil; McEvoy, John; Kicia, Marta.
Afiliación
  • Kopacz Z; Department of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, Poland.
  • Kvác M; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceské Budejovice, Czechia.
  • Karpinski P; Faculty of Agriculture, University of South Bohemia, Ceské Budejovice, Czechia.
  • Hendrich AB; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland.
  • Sasiadek MM; Department of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, Poland.
  • Leszczynski P; Department of Genetics, Wroclaw Medical University, Wroclaw, Poland.
  • Sak B; Department of Biology and Medical Parasitology, Wroclaw Medical University, Wroclaw, Poland.
  • McEvoy J; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceské Budejovice, Czechia.
  • Kicia M; Department of Microbiological Sciences, North Dakota State University, Fargo, ND, United States.
Front Cell Infect Microbiol ; 9: 35, 2019.
Article en En | MEDLINE | ID: mdl-30886833
Objectives: The potential linkage between Cryptosporidium spp. infection and colorectal human cancer was suggested by limited reports showing higher prevalence of C. parvum and C. hominis in patients with colon cancer. Here we conducted research concerning presence of Cryptosporidium spp. in malignant tissue collected from patients with colorectal cancer. Methods: Cancerous colon tissue samples collected from 145 non-HIV infected patients with colorectal cancer were screened for Cryptosporidium spp. by immunofluorescence antibody test and genus-specific nested polymerase chain reaction followed by sequencing. Results: Screened pathogen was found in cancerous tissue originating from immunocompetent man with colon adenocarcinoma. Genotyping revealed presence of Cryptosporidium meleagridis. The presence of Cryptosporidium life cycle stages (oocysts and endogenous stages) in colon carcinoma tissue was confirmed by genus-specific FITC-labeling. Conclusions: Herein, we report on a C. meleagridis infection of a colon adenocarcinoma in an immunocompetent patient. This is the first report of C. meleagridis infection in the human colon and first evidence of active development of this species in cancer tissue.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Neoplasias del Colon / Criptosporidiosis / Cryptosporidium Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Neoplasias del Colon / Criptosporidiosis / Cryptosporidium Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza