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Serum cholesterol positively associated with oxidative DNA damage: a propensity score-matched analysis.
Wei, Ya-Ping; Jia, Chao-Nan; Lan, Yuan; Hou, Xiang-Qing; Zuo, Jing-Jing; Cui, Huan; Guan, Xiao-Ju; Wang, Yi; Mao, Guang-Yun.
Afiliación
  • Wei YP; a Department of Preventive Medicine , School of Public Health and Management, Wenzhou Medical University , Wenzhou , China.
  • Jia CN; b Center on Evidence-Based Medicine & Clinical Epidemiological Research , School of Public Health, Wenzhou Medical University , Wenzhou , China.
  • Lan Y; a Department of Preventive Medicine , School of Public Health and Management, Wenzhou Medical University , Wenzhou , China.
  • Hou XQ; b Center on Evidence-Based Medicine & Clinical Epidemiological Research , School of Public Health, Wenzhou Medical University , Wenzhou , China.
  • Zuo JJ; c School of Ophthalmology & Optometry, Wenzhou Medical University , Wenzhou , China.
  • Cui H; a Department of Preventive Medicine , School of Public Health and Management, Wenzhou Medical University , Wenzhou , China.
  • Guan XJ; b Center on Evidence-Based Medicine & Clinical Epidemiological Research , School of Public Health, Wenzhou Medical University , Wenzhou , China.
  • Wang Y; c School of Ophthalmology & Optometry, Wenzhou Medical University , Wenzhou , China.
  • Mao GY; a Department of Preventive Medicine , School of Public Health and Management, Wenzhou Medical University , Wenzhou , China.
Free Radic Res ; 53(4): 411-417, 2019 Apr.
Article en En | MEDLINE | ID: mdl-30885010
Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A total of 407 participants chronically exposed to arsenic via drinking water from China were enrolled. Oxidative DNA damage was determined with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). Serum TC was classified into favourable TC (FTC, TC <5.18 mmol/L) and unfavourable TC (NFTC, TC ≥5.18 mmol/L) categories. Multivariable generalised linear regression model was applied to examine the association. Of 407 participants, 125 pairs with FTC and NFTC subjects were matched using PSM. Urinary 8-OHdG/creatinine levels in NFTC were significantly higher than those in FTC category (p = .002). As compared to the counterparts, additional adjusted log-transformed 8-OHdG/creatinine increase was observed in NFTC for unmatched (ß = 0.12, p = .052) and matched (ß = 0.17, p < .001) participants, respectively. We also detected obviously increased log-transformed urinary 8-OHdG/creatinine with per interquartile range raise of serum TC either in unmatched (ß = 0.10, p = .007) or matched (ß = 0.16, p = .003) subjects. In conclusion, serum TC was independently associated with oxidative DNA damage. Our findings provided new insights on the health promotion of lipids relevant to the early warning of diseases due to oxidative DNA damage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Biomarcadores / Colesterol / Exposición Profesional / Estrés Oxidativo / Puntaje de Propensión Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Free Radic Res Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Biomarcadores / Colesterol / Exposición Profesional / Estrés Oxidativo / Puntaje de Propensión Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Free Radic Res Asunto de la revista: BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido