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Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study.
Girgis, Ragy R; Baker, Seth; Mao, Xiangling; Gil, Roberto; Javitt, Daniel C; Kantrowitz, Joshua T; Gu, Meng; Spielman, Daniel M; Ojeil, Najate; Xu, Xiaoyan; Abi-Dargham, Anissa; Shungu, Dikoma C; Kegeles, Lawrence S.
Afiliación
  • Girgis RR; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA. Electronic address: ragy.girgis@nyspi.columbia.edu.
  • Baker S; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
  • Mao X; Department of Radiology, Weill Cornell Medical College, New York, USA.
  • Gil R; Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, USA.
  • Javitt DC; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
  • Kantrowitz JT; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
  • Gu M; Department of Radiology, Stanford University, Stanford, CA, USA.
  • Spielman DM; Department of Radiology, Stanford University, Stanford, CA, USA.
  • Ojeil N; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
  • Xu X; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
  • Abi-Dargham A; Department of Psychiatry, Stony Brook University School of Medicine, Stony Brook, USA.
  • Shungu DC; Department of Radiology, Weill Cornell Medical College, New York, USA.
  • Kegeles LS; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.
Psychiatry Res ; 275: 78-85, 2019 05.
Article en En | MEDLINE | ID: mdl-30884334
Findings from in vivo brain proton magnetic resonance spectroscopy (1H MRS) and preclinical studies have suggested region- and medication status-dependent increases in glutamate (Glu) levels and deficiencies in glutathione (GSH) levels in schizophrenia. N-acetylcysteine (NAC), a GSH synthesis precursor, has demonstrated modest clinical benefit in schizophrenia. The objective of this study was to examine the effects of acute administration of NAC on GSH and Glu levels measured with 1H MRS in 19 patients with schizophrenia and 20 healthy control subjects. Levels of GSH were acquired in dorsal anterior cingulate cortex (dACC), and those of Glu in dACC and medial prefrontal cortex (mPFC), at baseline and 60 min following acute oral administration of 2400 mg of NAC. No differences in the levels of GSH or Glu were found at baseline or following NAC administration between patients with schizophrenia and control subjects in either of the targeted brain regions. Future studies measuring GSH levels in brain regions previously found to exhibit glutamatergic abnormalities or using genetic polymorphisms, while controlling for the age and medication status of the cohorts, are warranted to better identify groups of patients more likely to respond to NAC and its mode of action and mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcisteína / Esquizofrenia / Depuradores de Radicales Libres / Corteza Prefrontal / Ácido Glutámico / Glutatión / Giro del Cíngulo Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcisteína / Esquizofrenia / Depuradores de Radicales Libres / Corteza Prefrontal / Ácido Glutámico / Glutatión / Giro del Cíngulo Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Psychiatry Res Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda