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Increased Intra-abdominal Pressure Induces Acute Kidney Injury in an Experimental Model of Congestive Heart Failure.
Abu-Saleh, Niroz; Aronson, Doron; Khamaisi, Mogher; Khoury, Emad E; Awad, Hoda; Kabala, Aviva; Ramadan, Rawi; Karram, Tony; Kakiashvili, Eli; Bishara, Bishara; Abassi, Zaid.
Afiliación
  • Abu-Saleh N; Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology.
  • Aronson D; Department of Cardiology.
  • Khamaisi M; Department of Diabetes and Metabolism and Internal Medicine, Institute of Endocrinology.
  • Khoury EE; Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology.
  • Awad H; Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology.
  • Kabala A; Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology.
  • Ramadan R; Department of Nephrology.
  • Karram T; Department of Vascular Surgery.
  • Kakiashvili E; Department of General Surgery.
  • Bishara B; Department of General Surgery.
  • Abassi Z; Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology; Department of Laboratory Medicine, Rambam Health Care Campus, Haifa, Israel. Electronic address: abassi@tx.technion.ac.il.
J Card Fail ; 25(6): 468-478, 2019 Jun.
Article en En | MEDLINE | ID: mdl-30880249
BACKGROUND: Congestive heart failure (CHF) entails a complex interaction between the heart and the kidney that represents a clinical entity called cardiorenal syndrome (CRS). One of the mechanisms underlying CRS includes increased intra-abdominal pressure (IAP). We examined the effect of elevated IAP on kidney function in rats with low- and high-output CHF. METHODS AND RESULTS: Rats with compensated and decompensated CHF induced by means of aortocaval fistula, rats with myocardial infraction (MI) induced by means of left anterior descending artery ligation, and sham control rats were subjected to either 10 or 14 mm Hg IAP. Urine flow (V), Na+ excretion (UNaV), glomerular filtration rate (GFR), and renal plasma flow (RPF) were determined. The effects of pretreatment with tadalafil (10 mg/kg orally for 4 days) on the adverse renal effects of IAP were examined in decompensated CHF and MI. Basal V and GFR were significantly lower in rats with decompensated CHF compared with sham control rats. Decompensated CHF rats and MI rats subjected to 10 and 14 mm Hg IAP exhibited more significant declines in V, UNaV, GFR and RPF than compensated and sham controls. Elevated IAP also induced tubular injury, as evidenced by significantly increased absolute urinary excretion of neutrophil gelatinase-associated lipocalin. In addition, in a nonquantitative histologic analysis, elevated IAP was associated with increase in necrosis and cell shedding to the tubule lumens, especially in the decompensated CHF subgroup. Pretreatment of decompensated CHF rats and MI rats with tadalafil ameliorated the adverse renal effects of high IAP. CONCLUSIONS: Elevated IAP contributes to kidney dysfunction in high- and low-cardiac output CHF. IAP induces both hemodynamic alterations and renal tubular dysfunction. These deleterious effects are potentially reversible and can be ameliorated with the use of phosphodiesterase-5 inhibition.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / Lesión Renal Aguda / Insuficiencia Cardíaca Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: J Card Fail Asunto de la revista: CARDIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Modelos Animales de Enfermedad / Lesión Renal Aguda / Insuficiencia Cardíaca Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: J Card Fail Asunto de la revista: CARDIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos