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Improved in vivo targeting of BCL-2 phenotypic conversion through hollow gold nanoshell delivery.
Morgan, Erin; Gamble, John T; Pearce, Martin C; Elson, Daniel J; Tanguay, Robert L; Kolluri, Siva Kumar; Reich, Norbert O.
Afiliación
  • Morgan E; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA. emorgan@chem.ucsb.edu.
  • Gamble JT; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
  • Pearce MC; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
  • Elson DJ; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
  • Tanguay RL; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
  • Kolluri SK; Linus Pauling Institute, Oregon State University, Corvallis, OR, 97331, USA.
  • Reich NO; Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR, 97331, USA.
Apoptosis ; 24(5-6): 529-537, 2019 06.
Article en En | MEDLINE | ID: mdl-30879165
Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56.4%.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Proteínas Proto-Oncogénicas c-bcl-2 / Nanocáscaras / Oro / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Apoptosis Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Proteínas Proto-Oncogénicas c-bcl-2 / Nanocáscaras / Oro / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Apoptosis Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos