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A Mixed-Methods Study Examining Adherence to and Acceptability of Intravaginal Rings for HIV Prevention: Behavioral Results of MTN-027.
Bauermeister, José A; Golinkoff, Jesse M; Carballo-Diéguez, Alex; Giguere, Rebecca; López, Daniela; Hoesley, Craig J; Chen, Beatrice A; Anderson, Peter; Dezzutti, Charlene S; Strizki, Julie; Sprinkle, Carol; Heard, Faye; Hall, Wayne; Jacobson, Cindy; Berthiaume, Jennifer; Mayo, Ashley; Richardson, Barbra A; Piper, Jeanna.
Afiliación
  • Bauermeister JA; School of Nursing, University of Pennsylvania, 418 Curie Blvd., Suite 222L, Philadelphia, PA, 19104, USA. bjose@upenn.edu.
  • Golinkoff JM; School of Nursing, University of Pennsylvania, 418 Curie Blvd., Suite 222L, Philadelphia, PA, 19104, USA.
  • Carballo-Diéguez A; Department of Psychiatry, Columbia University, New York, USA.
  • Giguere R; HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, New York, NY, USA.
  • López D; Department of Psychiatry, Columbia University, New York, USA.
  • Hoesley CJ; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
  • Chen BA; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Anderson P; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Dezzutti CS; Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Strizki J; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.
  • Sprinkle C; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Heard F; Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Hall W; Merck & Co. Inc., Kenilworth, NJ, USA.
  • Jacobson C; University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Berthiaume J; School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Mayo A; Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Richardson BA; Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Piper J; Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
AIDS Behav ; 24(2): 607-616, 2020 Feb.
Article en En | MEDLINE | ID: mdl-30877580
Intravaginal rings (IVR) containing antiretroviral drugs are a promising method for HIV prevention. We triangulated quantitative and qualitative assessments to evaluate the acceptability of four IVRs used continuously for 28 days as part of a Phase I trial (N = 48 HIV-negative women; ages 18-45). Adherence was high throughout the trial, yet 30% of participants reported involuntary IVR expulsions followed by re-insertion. Most participants (93.6%) felt comfortable with the IVR being inside their body. Participants reported liking the IVR more (36.2%) or the same amount (55.3%) since starting the study. When given the option of choosing between the IVR and/or a male condom for HIV-prevention, most reported preferring the IVR (n = 29, 63.0%), and over a quarter of the sample reported liking them equally (n = 12, 26.1%). We observed no differences in IVR acceptability across the study arms. High adherence and acceptability underscores the promise of an IVR as a female-controlled, sustained mechanism for HIV prevention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cremas, Espumas y Geles Vaginales / Aceptación de la Atención de Salud / Infecciones por VIH / Antirretrovirales / Cumplimiento de la Medicación / Antiinfecciosos Tipo de estudio: Qualitative_research Límite: Adolescent / Adult / Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: AIDS Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cremas, Espumas y Geles Vaginales / Aceptación de la Atención de Salud / Infecciones por VIH / Antirretrovirales / Cumplimiento de la Medicación / Antiinfecciosos Tipo de estudio: Qualitative_research Límite: Adolescent / Adult / Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: AIDS Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos