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Recombinant human thyrotropin (rhTSH) versus Levo-thyroxine withdrawal in radioiodine therapy of differentiated thyroid cancer patients: differences in abdominal absorbed dose.
Campennì, Alfredo; Amato, Ernesto; Laudicella, Riccardo; Alibrandi, Angela; Cardile, Davide; Pignata, Salvatore Antonio; Trimarchi, Francesco; Ruggeri, Rosaria Maddalena; Auditore, Lucrezia; Baldari, Sergio.
Afiliación
  • Campennì A; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy. acampenni@unime.it.
  • Amato E; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.
  • Laudicella R; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.
  • Alibrandi A; Department of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Messina, Italy.
  • Cardile D; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.
  • Pignata SA; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.
  • Trimarchi F; Accademia Peloritana dei Pericolanti at the University of Messina, Messina, Italy.
  • Ruggeri RM; Department of Clinical and Experimental Medicine, Unit of Endocrinology, University of Messina, Messina, Italy.
  • Auditore L; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.
  • Baldari S; Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy.
Endocrine ; 65(1): 132-137, 2019 07.
Article en En | MEDLINE | ID: mdl-30875058
PURPOSE: In DTC patients, 131-radioiodine therapy has routinely been used for many years for thyroid remnant ablation after thyroid surgery. To date, two different strategies can be used to achieve sufficient TSH stimulation on thyroid remnant: (I) Levo-thyroxine withdrawal or (II) rhTSH stimulation. The aim of our study was to compare the abdominal absorbed dose ratio between differentiated thyroid cancer patients who underwent thyroid remnant ablation after either L-T4 withdrawal or rhTSH stimulation. METHODS: We reviewed the records of 63 patients affected by differentiated thyroid cancer. All patients underwent thyroid remnant ablation after either L-T4 withdrawal or rhTSH stimulation. A post-therapy whole-body scan was obtained 5 days after 131-radioiodine therapy. Qualitative and quantitative image analysis was performed. Quantitative analysis was performed by drawing seven regions of interest on the abdomen (anterior and posterior views) to estimate both the activity ratio (AR) and absorbed dose ratio (DR) obtained in patients treated in hypothyroidism or after rhTSH stimulation. RESULTS: The values of the activity and absorbed dose ratios obtained on each abdomen region (liver, stomach, ascending colon, transverse colon, descending colon, rectum, and small intestine) were always higher in patients treated after L-T4 withdrawal than after rhTSH stimulation with p-values of 0.000, 0.000, 0.001, 0.000, 0.022, 0.007, and 0.002, respectively. CONCLUSIONS: DTC patients treated with 131-radioiodine after rhTSH stimulation have lower abdominal radioiodine activity than hypothyroid patients. Our data could be of practical relevance in terms of patient management. The potential impact on rare radioiodine-related gastrointestinal side effects is to be established in specifically designed prospective studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroxina / Neoplasias de la Tiroides / Tirotropina / Adenocarcinoma / Abdomen / Radioisótopos de Yodo Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Endocrine Asunto de la revista: ENDOCRINOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroxina / Neoplasias de la Tiroides / Tirotropina / Adenocarcinoma / Abdomen / Radioisótopos de Yodo Tipo de estudio: Etiology_studies / Observational_studies / Qualitative_research / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Endocrine Asunto de la revista: ENDOCRINOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos