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Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial.
Furlong, Orlaith N; Parr, Heather J; Hodge, Stephanie J; Slevin, Mary M; Simpson, Ellen E; McSorley, Emeir M; McCormack, Jacqueline M; Magee, Pamela J.
Afiliación
  • Furlong ON; Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.
  • Parr HJ; Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.
  • Hodge SJ; University of East Anglia, Norwich, UK.
  • Slevin MM; Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.
  • Simpson EE; Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.
  • McSorley EM; Psychology Research Institute, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.
  • McCormack JM; Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.
  • Magee PJ; Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.
Eur J Nutr ; 59(2): 755-766, 2020 Mar.
Article en En | MEDLINE | ID: mdl-30863894
PURPOSE: Cognitive decline is commonly reported during the menopausal transition, with memory and attention being particularly affected. The aim of this study was to investigate the effects of a commercially available soy drink on cognitive function and menopausal symptoms in post-menopausal women. METHODS: 101 post-menopausal women, aged 44-63 years, were randomly assigned to consume a volume of soy drink providing a low (10 mg/day; control group), medium (35 mg/day), or high (60 mg/day) dose of isoflavones for 12 weeks. Cognitive function (spatial working memory, spatial span, pattern recognition memory, 5-choice reaction time, and match to sample visual search) was assessed using CANTAB pre- and post-the 12 week intervention. Menopausal symptoms were assessed using Greene's Climacteric Scale. RESULTS: No significant differences were observed between the groups for any of the cognitive function outcomes measured. Soy drink consumption had no effect on menopausal symptoms overall; however, when women were stratified according to the severity of vasomotor symptoms (VMS) at baseline, women with more severe symptoms at baseline in the medium group had a significant reduction (P = 0.001) in VMS post-intervention (mean change from baseline score: - 2.15 ± 1.73) in comparison to those with less severe VMS (mean change from baseline score: 0.06 ± 1.21). CONCLUSIONS: Soy drink consumption had no effect on cognitive function in post-menopausal women. Consumption of ~ 350 ml/day (35 mg IFs) for 12 weeks significantly reduced VMS in those with more severe symptoms at baseline. This finding is clinically relevant as soy drinks may provide an alternative, natural, treatment for alleviating VMS, highly prevalent among western women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Vasomotor / Cognición / Posmenopausia / Leche de Soja Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Vasomotor / Cognición / Posmenopausia / Leche de Soja Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article Pais de publicación: Alemania