Design and characterization of a novel Arthrospira platensis glutathione oxido-reductase-derived antioxidant peptide GM15 and its potent anti-cancer activity via caspase-9 mediated apoptosis in oral cancer cells.

Sannasimuthu, Anbazahan; Kumaresan, Venkatesh; Anilkumar, Shreya; Pasupuleti, Mukesh; Ganesh, Munuswamy-Ramanujam; Mala, Kanchana; Paray, Bilal Ahmad; Al-Sadoon, Mohammad K; Albeshr, Mohammed Fahad; Arockiaraj, Jesu

Sannasimuthu, Anbazahan; Kumaresan, Venkatesh; Anilkumar, Shreya; Pasupuleti, Mukesh; Ganesh, Munuswamy-Ramanujam; Mala, Kanchana; Paray, Bilal Ahmad; Al-Sadoon, Mohammad K; Albeshr, Mohammed Fahad; Arockiaraj, Jesu.

Afiliación

Sannasimuthu A; Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India.
Kumaresan V; Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India.
Anilkumar S; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India.
Pasupuleti M; Lab PCN 206, Microbiology Division, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, Uttar Pradesh, India.
Ganesh MR; Interdisciplinary Institute of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India.
Mala K; Department of Medical Research, Medical College Hospital and Research Center, SRM Institute of Science and Technology, Kattankulathur, 603 203 Chennai, Tamil Nadu, India.
Paray BA; Department of Zoology, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.
Al-Sadoon MK; Department of Zoology, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.
Albeshr MF; Department of Zoology, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia.
Arockiaraj J; SRM Research Institute, SRM Institute of Science and Technology, Kattankulathur 603 203, Chennai, Tamil Nadu, India. Electronic address: jesuarockiaraj.a@ktr.srmuniv.ac.in.

Free Radic Biol Med ; 135: 198-209, 2019 05 01.

Article en En | MEDLINE | ID: mdl-30862544

Asunto(s)

Antioxidantes/farmacología; Neoplasias de la Boca/tratamiento farmacológico; Péptidos/farmacología; Spirulina/enzimología; Antioxidantes/química; Apoptosis/efectos de los fármacos; Caspasa 9/genética; Catalasa/genética; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Glutatión Reductasa/química; Glutatión Reductasa/genética; Humanos; Neoplasias de la Boca/metabolismo; Neoplasias de la Boca/patología; Oxidación-Reducción; Péptidos/química; Superóxido Dismutasa/genética

Palabras clave

Antioxidant; Apoptosis; Dithiol peptide; Glutathione oxido-reductase; Oral carcinoma cells

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Neoplasias de la Boca / Spirulina / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos

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