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Inhibitory effects of scoparone from chestnut inner shell on platelet-derived growth factor-BB-induced vascular smooth muscle cell migration and vascular neointima hyperplasia.
Jung, Seung Hyo; Lee, Gyoung Beom; Ryu, Yunkyoung; Cui, Long; Lee, Hwan Myung; Kim, Junghwan; Kim, Bokyung; Won, Kyung Jong.
Afiliación
  • Jung SH; Department of Physiology, School of Medicine, Konkuk University, Seoul, South Korea.
  • Lee GB; Department of Physiology, School of Medicine, Konkuk University, Seoul, South Korea.
  • Ryu Y; Department of Physiology, School of Medicine, Konkuk University, Seoul, South Korea.
  • Cui L; Department of Physiology, School of Medicine, Konkuk University, Seoul, South Korea.
  • Lee HM; Department of Cosmetic Science, College of Natural Science, Hoseo University, Asan, South Korea.
  • Kim J; Department of Physical Therapy, College of Public Health & Welfare, Yongin University, Yongin, South Korea.
  • Kim B; Department of Physiology, School of Medicine, Konkuk University, Seoul, South Korea.
  • Won KJ; Department of Physiology, School of Medicine, Konkuk University, Seoul, South Korea.
J Sci Food Agric ; 99(9): 4397-4406, 2019 Jul.
Article en En | MEDLINE | ID: mdl-30861122
BACKGROUND: Compounds of the inner shell of chestnut (Castanea crenata) have diverse biological activities, including anti-cancer and anti-oxidant activities. Here we explored the effects of an extract of chestnut inner shells and of its bioactive component scoparone on vascular smooth muscle cell migration and vessel damage. RESULTS: The ethanol extract of chestnut inner shells, containing 11 major compounds, inhibited platelet-derived growth factor (PDGF)-BB-induced migration of rat aortic smooth muscle cells (RASMCs). Among these compounds, scoparone (6,7-dimethoxycoumarin) suppressed RASMC migration and wound healing in response to PDGF-BB but did not affect RASMC proliferation. In RASMCs, scoparone inhibited the PDGF-BB-induced rat aortic sprout outgrowth and attenuated the PDGF-BB-mediated increase in phosphorylation of mitogen-activated protein kinases (MAPKs), p38 MAPK and extracellular signal-regulated kinase 1/2. The in vivo administration of scoparone resulted in the attenuation of neointima formation in balloon-injured carotid arteries of rats. CONCLUSION: These findings demonstrate that scoparone, found in chestnut inner shells, may inhibit cell migration through suppression of the phosphorylation of MAPKs in PDGF-BB-treated RASMCs, probably contributing to the reduction of neointimal hyperplasia induced after vascular injury. Therefore, scoparone and chestnut inner shell may be a potential agent or functional food, respectively, for the prevention of vascular disorders such as vascular restenosis or atherosclerosis. © 2019 Society of Chemical Industry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Cumarinas / Fagaceae / Miocitos del Músculo Liso / Neointima / Becaplermina / Hiperplasia / Músculo Liso Vascular Límite: Animals / Humans / Male Idioma: En Revista: J Sci Food Agric Año: 2019 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Cumarinas / Fagaceae / Miocitos del Músculo Liso / Neointima / Becaplermina / Hiperplasia / Músculo Liso Vascular Límite: Animals / Humans / Male Idioma: En Revista: J Sci Food Agric Año: 2019 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido