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Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats.
Cavalcante, Daniel Pereira; Turones, Larissa Córdova; Camargo-Silva, Gabriel; Santana, Joice Simões; Colugnati, Diego Basile; Pansani, Aline Priscila; Xavier, Carlos Henrique; Henschel Pobbe, Roger Luís.
Afiliación
  • Cavalcante DP; Systems Neurobiology Laboratory, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
  • Turones LC; Systems Neurobiology Laboratory, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
  • Camargo-Silva G; Systems Neurobiology Laboratory, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
  • Santana JS; Systems Neurobiology Laboratory, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
  • Colugnati DB; Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
  • Pansani AP; Integrative Laboratory of Cardiovascular and Neurological Pathophysiology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
  • Xavier CH; Systems Neurobiology Laboratory, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.
  • Henschel Pobbe RL; Systems Neurobiology Laboratory, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil; Biological Sciences Post-Graduation Program, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil. Electronic address: rogerlhp10@gmail.com.
Behav Brain Res ; 365: 178-184, 2019 06 03.
Article en En | MEDLINE | ID: mdl-30857770
Ghrelin is a recently discovered peptide, mainly produced in the stomach and involved in body's energy-maintenance processes. Ghrelin exerts its actions by activating the growth hormone secretagogue receptor (GHS-R). Recent analyses indicate that ghrelin targets the brain to regulate a wealth of functions, including behavioral responses that have been associated with stress and anxiety mechanisms. In this context, evidence shows the presence of GHS-R receptors in the dorsal raphe nucleus (DRN), the main source of serotonergic neurons that innervate encephalic structures involved in emotional control. Our study aims to evaluate the effects of the pharmacological manipulation of ghrelin receptors located in the DRN on the expression of the behavioral responses of Wistar rats. Such responses were assessed in the elevated T maze (ETM), an experimental model that allows the measurement, in the same animal, of two defensive tasks, inhibitory avoidance and escape. Our results showed that the intra-DRN infusion of ghrelin impaired the acquisition of inhibitory avoidance, an anxiolytic-like effect, and facilitated the expression of escape response in the ETM, indicating a panicogenic-like effect. The intra-DRN administration of the ghrelin receptor (GHS-R1a) antagonist PF-04628935 did not alter the behavioral tasks assessed in the ETM. Finally, our results revealed that intra-DRN infusions of PF-04628935 prior to the administration of ghrelin into this area neutralized the behavioral effects obtained in the ETM. Taken together, our data reveal the involvement of DRN GHS-R1a receptors in the regulation of defensive tasks that have been associated with generalized anxiety and panic disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Reacción de Fuga / Receptores de Ghrelina / Núcleo Dorsal del Rafe Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reacción de Prevención / Reacción de Fuga / Receptores de Ghrelina / Núcleo Dorsal del Rafe Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos