Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.

Saez Cabodevilla, Jaione; Volbeda, Anne; Hamelin, Olivier; Latour, Jean-Marc; Gigarel, Océane; Clémancey, Martin; Darnault, Claudine; Reichmann, Debora; Amara, Patricia; Fontecilla-Camps, Juan C; Ollagnier de Choudens, Sandrine

Saez Cabodevilla, Jaione; Volbeda, Anne; Hamelin, Olivier; Latour, Jean-Marc; Gigarel, Océane; Clémancey, Martin; Darnault, Claudine; Reichmann, Debora; Amara, Patricia; Fontecilla-Camps, Juan C; Ollagnier de Choudens, Sandrine.

Afiliación

Saez Cabodevilla J; Univ. Grenoble Alpes, CEA, CNRS, BIG-LCBM, UMR5249, 38000, Grenoble, France. sollagnier@cea.fr.

Chem Commun (Camb) ; 55(26): 3725-3728, 2019 Mar 26.

Article en En | MEDLINE | ID: mdl-30855610

RESUMEN

Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

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