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Variable outcomes of human heart attack recapitulated in genetically diverse mice.
Salimova, Ekaterina; Nowak, Kristen J; Estrada, Ana C; Furtado, Milena B; McNamara, Elyshia; Nguyen, Quang; Balmer, Lois; Preuss, Christoph; Holmes, Jeffrey W; Ramialison, Mirana; Morahan, Grant; Rosenthal, Nadia A.
Afiliación
  • Salimova E; 1Australian Regenerative Medicine Institute, Monash University, Clayton, VIC Australia.
  • Nowak KJ; 2Monash Biomedical Imaging, Monash University, Clayton, VIC Australia.
  • Estrada AC; 3Faculty of Health and Medical Sciences, School of Biomedical Sciences, The University of Western Australia, Perth, WA Australia.
  • Furtado MB; 4QEII Medical Centre, Nedlands and Centre for Medical Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, WA Australia.
  • McNamara E; 5Office of Population Health Genomics, Division of Public and Aboriginal Health, Western Australian Department of Health, East Perth, WA Australia.
  • Nguyen Q; 6Departments of Biomedical Engineering and Medicine, and Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA USA.
  • Balmer L; 1Australian Regenerative Medicine Institute, Monash University, Clayton, VIC Australia.
  • Preuss C; 7The Jackson Laboratory, Bar Harbor, ME USA.
  • Holmes JW; 3Faculty of Health and Medical Sciences, School of Biomedical Sciences, The University of Western Australia, Perth, WA Australia.
  • Ramialison M; 4QEII Medical Centre, Nedlands and Centre for Medical Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, WA Australia.
  • Morahan G; 4QEII Medical Centre, Nedlands and Centre for Medical Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, WA Australia.
  • Rosenthal NA; 4QEII Medical Centre, Nedlands and Centre for Medical Research, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, WA Australia.
NPJ Regen Med ; 4: 5, 2019.
Article en En | MEDLINE | ID: mdl-30854227
Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterized responses to acute MI in the Collaborative Cross (CC), a multi-parental panel of genetically diverse mouse strains. Striking differences in post-MI functional, morphological, and myocardial scar features were detected across 32 CC founder and recombinant inbred strains. Transcriptomic analyses revealed a plausible link between increased intrinsic cardiac oxidative phosphorylation levels and MI-induced heart failure. The emergence of significant quantitative trait loci for several post-MI traits indicates that utilizing CC strains is a valid approach for gene network discovery in cardiovascular disease, enabling more accurate clinical risk assessment and prediction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: NPJ Regen Med Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: NPJ Regen Med Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos