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Rat Left Ventricular Cardiomyocytes Characterization in the Process of Postinfarction Myocardial Remodeling.
Baidyuk, Ekaterina V; Sakuta, Galina A; Vorobev, Mikhail L; Stepanov, Andrei V; Karpov, Andrei A; Rogoza, Olga V; Kudryavtsev, Boris N.
Afiliación
  • Baidyuk EV; Laboratory of Cell Pathology, Institute of Cytology of the Russian Academy of Sciences, Saint-Petersburg, Russia.
  • Sakuta GA; Laboratory of Cell Pathology, Institute of Cytology of the Russian Academy of Sciences, Saint-Petersburg, Russia.
  • Vorobev ML; Laboratory of Cell Pathology, Institute of Cytology of the Russian Academy of Sciences, Saint-Petersburg, Russia.
  • Stepanov AV; Laboratory of Cell Pathology, Institute of Cytology of the Russian Academy of Sciences, Saint-Petersburg, Russia.
  • Karpov AA; Laboratory of Nanotechnology, Almazov National Medical Research Center, Saint-Petersburg, Russia.
  • Rogoza OV; Pathoanatomic laboratory of medical rehabilitation complex, Almazov National Medical Research Center, Saint-Petersburg, Russia.
  • Kudryavtsev BN; Laboratory of Cell Pathology, Institute of Cytology of the Russian Academy of Sciences, Saint-Petersburg, Russia.
Cytometry A ; 95(7): 730-736, 2019 07.
Article en En | MEDLINE | ID: mdl-30852842
Ischemic lesions of the heart, including myocardial infarction, are the most common pathologies of human cardiovascular system. Despite all the research and achievements of medicine in this field, the mortality from this disease remains heavy. Therefore, studying of processes occurring in the myocardium in the early and late postinfarction periods remains important. Rat left ventricular cardiomyocyte (CMC) ploidy, hypertrophy, hyperplasia, and ultrastructure were investigated in 2, 6, and 26 weeks after experimental myocardial infarction, caused by permanent ligation of left coronary artery. Cytofluorimetric study of CMC ploidy revealed no difference between normal, sham-operated, and infarcted animals for all the tested stages. However, interference microscopy indicated significant changes in cells size. CMC dry mass of infarcted rats in 2 weeks after surgery was 1.5 times lower than in control and sham operated groups. Electron microscopy analysis of CMC revealed disruption of sarcomere structure. However, in 6 weeks after surgery CMC dry mass was 1.6 times higher than in control. In 26 weeks after myocardial infarction CMC dry mass exceeded control only in peri-infarction zone. Cell counting showed that the number of left ventricular CMC, reduced as a result of myocardial infarction, was not restored during myocardial remodeling. © 2019 International Society for Advancement of Cytometry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcómeros / Miocitos Cardíacos / Infarto del Miocardio / Miocardio Límite: Animals Idioma: En Revista: Cytometry A Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcómeros / Miocitos Cardíacos / Infarto del Miocardio / Miocardio Límite: Animals Idioma: En Revista: Cytometry A Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos