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A Review on the Scope of Photothermal Therapy-Based Nanomedicines in Preclinical Models of Colorectal Cancer.
Khot, M Ibrahim; Andrew, Helen; Svavarsdottir, Hafdis S; Armstrong, Gemma; Quyn, Aaron J; Jayne, David G.
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  • Khot MI; School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK. Electronic address: M.I.Khot@leeds.ac.uk.
  • Andrew H; School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK.
  • Svavarsdottir HS; School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK.
  • Armstrong G; School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK.
  • Quyn AJ; School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK.
  • Jayne DG; School of Medicine, St James's University Hospital, University of Leeds, Leeds, UK.
Clin Colorectal Cancer ; 18(2): e200-e209, 2019 06.
Article en En | MEDLINE | ID: mdl-30852125
Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents. An advantage of nanomedicines is their multifunctionality, with the capability to deliver combinations of chemotherapeutics and cancer-imaging agents. To date, there have been no clinical studies evaluating photothermal therapy-based nanomedicines in colorectal cancers. This review presents the current scope of preclinical studies, investigating nanomedicines that have been developed for delivering multimodal photothermal therapy to colorectal cancers, with an emphasis on potential clinical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fototerapia / Neoplasias Colorrectales / Fármacos Fotosensibilizantes / Nanopartículas / Técnicas de Ablación / Hipertermia Inducida Límite: Animals / Humans Idioma: En Revista: Clin Colorectal Cancer Asunto de la revista: GASTROENTEROLOGIA / NEOPLASIAS Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fototerapia / Neoplasias Colorrectales / Fármacos Fotosensibilizantes / Nanopartículas / Técnicas de Ablación / Hipertermia Inducida Límite: Animals / Humans Idioma: En Revista: Clin Colorectal Cancer Asunto de la revista: GASTROENTEROLOGIA / NEOPLASIAS Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos