Isolation and characterization of resveratrol oligomers from the stem bark of Hopea ponga (Dennst.) Mabb. And their antidiabetic effect by modulation of digestive enzymes, protein glycation and glucose uptake in L6 myocytes.

Sasikumar, P; Lekshmy, K; Sini, S; Prabha, B; Kumar, N Anil; Sivan, V V; Jithin, M M; Jayamurthy, P; Shibi, I G; Radhakrishnan, K V

Sasikumar, P; Lekshmy, K; Sini, S; Prabha, B; Kumar, N Anil; Sivan, V V; Jithin, M M; Jayamurthy, P; Shibi, I G; Radhakrishnan, K V.

Afiliación

Sasikumar P; Chemical Science and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India.
Lekshmy K; Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India.
Sini S; Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India.
Prabha B; Chemical Science and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India.
Kumar NA; M. S. Swaminathan Research Foundation-Community Agrobiodiversity Centre (MSSRF-CAbC), Puthurvayal, Wayanad, Kerala, India.
Sivan VV; M. S. Swaminathan Research Foundation-Community Agrobiodiversity Centre (MSSRF-CAbC), Puthurvayal, Wayanad, Kerala, India.
Jithin MM; M. S. Swaminathan Research Foundation-Community Agrobiodiversity Centre (MSSRF-CAbC), Puthurvayal, Wayanad, Kerala, India.
Jayamurthy P; Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India; Academy of Scientific and Innovative Research (AcSIR), Thiruvananthapuram, 695019, India.
Shibi IG; Department of Chemistry, Sree Narayana College, Chempazhanthy, Thiruvananthapuram, Kerala, India.
Radhakrishnan KV; Chemical Science and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, 695019, India; Academy of Scientific and Innovative Research (AcSIR), Thiruvananthapuram, 695019, India. Electronic address: radhu2005@gmail.com.

J Ethnopharmacol ; 236: 196-204, 2019 May 23.

Article en En | MEDLINE | ID: mdl-30844488

Asunto(s)

Dipterocarpaceae/química; Hipoglucemiantes/farmacología; Extractos Vegetales/farmacología; Resveratrol/farmacología; Acetona/química; Animales; Línea Celular; Diabetes Mellitus/tratamiento farmacológico; Pruebas de Enzimas; Etanol/química; Glicosilación/efectos de los fármacos; Hipoglucemiantes/química; Hipoglucemiantes/aislamiento & purificación; Concentración 50 Inhibidora; Medicina Tradicional/métodos; Simulación del Acoplamiento Molecular; Estructura Molecular; Mioblastos; Corteza de la Planta/química; Extractos Vegetales/química; Tallos de la Planta/química; Ratas; Resveratrol/química; Resveratrol/aislamiento & purificación; Pruebas de Toxicidad; alfa-Amilasas/antagonistas & inhibidores; alfa-Amilasas/química; alfa-Amilasas/metabolismo; alfa-Glucosidasas/química; alfa-Glucosidasas/metabolismo

Palabras clave

2-NBDG uptake; Hopea ponga; MTT assay; Molecular docking; Resveratrol oligomers; α-Glucosidase inhibition

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Dipterocarpaceae / Resveratrol / Hipoglucemiantes Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Irlanda

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