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Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania.
Bristot, Giovana; Ascoli, Bruna M; Scotton, Ellen; Géa, Luiza P; Pfaffenseller, Bianca; Kauer-Sant'Anna, Márcia.
Afiliación
  • Bristot G; Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  • Ascoli BM; Programa de Pós-Graduação em Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
  • Scotton E; Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  • Géa LP; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, UFRGS, Porto Alegre, RS, Brazil.
  • Pfaffenseller B; Laboratório de Psiquiatria Molecular, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  • Kauer-Sant'Anna M; Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, UFRGS, Porto Alegre, RS, Brazil.
Braz J Psychiatry ; 41(5): 419-427, 2019.
Article en En | MEDLINE | ID: mdl-30843957
OBJECTIVE: To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by lipopolysaccharides (LPS) has a cumulative effect on subsequent stimuli in this model. We also evaluated the action of lithium (Li) on inflammatory and neurotrophic factors. METHODS: Adult male Wistar rats were subjected to an animal model of mania. After the open-field test, they were given LPS to induce systemic immune activation. Subsequently, the animals' blood was collected, and their serum levels of brain-derived neurotrophic factor and inflammatory markers (tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-1ß, IL-10, and inducible nitric oxide synthase [iNOS]) were measured. RESULTS: LDX induced hyperactivity in the animals, but no inflammatory marker levels increased except brain-derived neurotrophic factor (BDNF). Li had no effect on serum BDNF levels but prevented iNOS levels from increasing in animals subjected to immune activation. CONCLUSION: Although Li prevented an LPS-induced increase in serum iNOS levels, its potential anti-inflammatory effects in this animal model of mania were conflicting.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Modelos Animales de Enfermedad / Dimesilato de Lisdexanfetamina / Litio / Antiinflamatorios / Factores de Crecimiento Nervioso Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Braz J Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Modelos Animales de Enfermedad / Dimesilato de Lisdexanfetamina / Litio / Antiinflamatorios / Factores de Crecimiento Nervioso Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Braz J Psychiatry Asunto de la revista: PSIQUIATRIA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil