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Rho kinase inhibitors-a review on the physiology and clinical use in Ophthalmology.
Moura-Coelho, Nuno; Tavares Ferreira, Joana; Bruxelas, Carolina Pereira; Dutra-Medeiros, Marco; Cunha, João Paulo; Pinto Proença, Rita.
Afiliación
  • Moura-Coelho N; Ophthalmology Department, Centro Hospitalar Universitário Lisboa Central (CHULC), Alameda Santo António Capuchos, 1169-050, Lisbon, Portugal. nunomouracoelho.oft@gmail.com.
  • Tavares Ferreira J; Faculty of Medical Sciences|NOVA Medical School-Nova University of Lisbon (FCM|NMS-UNL), Lisbon, Portugal. nunomouracoelho.oft@gmail.com.
  • Bruxelas CP; Instituto Português de Retina (IPR), Lisbon, Portugal. nunomouracoelho.oft@gmail.com.
  • Dutra-Medeiros M; Associação Médica Olhar Bem (AMO Bem), Lisbon, Portugal. nunomouracoelho.oft@gmail.com.
  • Cunha JP; Ophthalmology Department, Centro Hospitalar Universitário Lisboa Central (CHULC), Alameda Santo António Capuchos, 1169-050, Lisbon, Portugal.
  • Pinto Proença R; Faculty of Medical Sciences|NOVA Medical School-Nova University of Lisbon (FCM|NMS-UNL), Lisbon, Portugal.
Graefes Arch Clin Exp Ophthalmol ; 257(6): 1101-1117, 2019 Jun.
Article en En | MEDLINE | ID: mdl-30843105
The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oftalmología / Enfermedades de la Retina / Glaucoma / Enfermedades de la Córnea / Quinasas Asociadas a rho Límite: Animals / Humans Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2019 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oftalmología / Enfermedades de la Retina / Glaucoma / Enfermedades de la Córnea / Quinasas Asociadas a rho Límite: Animals / Humans Idioma: En Revista: Graefes Arch Clin Exp Ophthalmol Año: 2019 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Alemania