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Association of miR-197-5p, a Circulating Biomarker for Heart Failure, with Myocardial Fibrosis and Adverse Cardiovascular Events among Patients with Stage C or D Heart Failure.
Liu, Wei; Zheng, Junmeng; Dong, Jianzeng; Bai, Rong; Song, Deli; Ma, Xiaohai; Zhao, Lei; Yao, Yan; Zhang, Haibo; Liu, Tong.
Afiliación
  • Liu W; Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, Beijing, China.
  • Zheng J; Department of Cardiothoracic Surgery, Second Affiliated Hospital of Sun Yat-Sen University, Guang Dong, China.
  • Dong J; Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, Beijing, China.
  • Bai R; Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, Beijing, China.
  • Song D; Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, Beijing, China.
  • Ma X; Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Zhao L; Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Yao Y; Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, Beijing, China.
  • Zhang H; Department of Cardiovascular Surgery, Beijing AnZhen Hospital, Capital Medical University, Beijing, China.
  • Liu T; Department of Cardiology, Beijing AnZhen Hospital, Capital Medical University, Beijing, China, ltanzhen@126.com.
Cardiology ; 141(4): 212-225, 2018.
Article en En | MEDLINE | ID: mdl-30836355
OBJECTIVE: The aim of this study was to identify heart failure (HF)-specific circulating micro-RNAs (miRNA), and examine whether the selected miRNAs correlate with myocardial fibrosis and are reflective of the incidence of adverse cardiovascular events in patients with stage C or D HF. METHODS: Circulating miRNAs which were expressed in end-stage HF patients and matched healthy controls were detected by microarray analysis and validated by quantitative real-time polymerase chain reaction. Multivariate Cox regression analysis was performed to determine whether the selected circulating miRNAs could be prognostic factors in HF patients. RESULTS: In a cohort of 7 healthy controls and 9 patients with stage C or D HF, 7 miRNAs were differentially expressed. These miRNAs were further investigated in a second cohort of 80 patients with stage C or D HF and 30 healthy controls. Only miR-197-5P correlated with fibrosis as seen in cardiac magnetic resonance imaging in patients under the age of 50 years with stage C or D HF (r = 0.42, p = 0.008). Multivariate analyses revealed that miR-197-5P was also a risk factor for composite endpoint events in patients under the age of 50 years with stage C or D HF. CONCLUSION: miR-197-5P is a circulation miRNA that correlates with MF and adverse cardiac events in HF patients under the age of 50 years.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / MicroARNs / Insuficiencia Cardíaca / Cardiomiopatías / Miocardio Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cardiology Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / MicroARNs / Insuficiencia Cardíaca / Cardiomiopatías / Miocardio Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cardiology Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza