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The tributyltin leads to obesogenic mammary gland abnormalities in adult female rats.
da Costa, Charles S; Miranda-Alves, Leandro; La Merrill, Michele A; Silva, Ian V; Graceli, Jones B.
Afiliación
  • da Costa CS; Dept of Morphology, Federal University of Espírito Santo, Brazil. Electronic address: chsantoscosta@hotmail.com.
  • Miranda-Alves L; Laboratory of Experimental Endocrinology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil; Postgraduate Program in Endocrinology, Faculty of Medicine and Postgraduate Program of Pharmacology and Medicinal Chemistry, Federal University of Rio de Janeiro, Brazil; Experim
  • La Merrill MA; Dept of Environmental Toxicology, University of California at Davis, USA. Electronic address: mlamerrill@ucdavis.edu.
  • Silva IV; Dept of Morphology, Federal University of Espírito Santo, Brazil. Electronic address: iasilv@yahoo.com.
  • Graceli JB; Dept of Morphology, Federal University of Espírito Santo, Brazil. Electronic address: jbgraceli@gmail.com.
Toxicol Lett ; 307: 59-71, 2019 Jun 01.
Article en En | MEDLINE | ID: mdl-30831249
Tributyltin chloride (TBT) is an obesogen associated with several complications. However, few investigations have evaluated TBT effects on adult mammary glands (MG). In this investigation, we assessed whether TBT's obesogenic effects resulted in abnormal MG fat pad expansion and other irregularities. TBT was administered to female rats (100 ng/kg/day for 15 days via gavage), and their MG morphophysiological development was assessed. We further assessed the MG fat pad for PPARγ, ERα, and aromatase protein expression, as well as inflammation, oxidative stress (OS), apoptosis and fibrosis. Irregular MG morphological development such as lower TEB number, alveolar (AB), lobule and differentiation (DF) score were observed in TBT rats. TBT rats had abnormal MG fat accumulation as evidenced by increased numbers of hypertrophic adipocytes, triglyceride (TG) levels and PPARγ expression. A strong negative correlation between the MG obesogenic makers and TEB number, AB and DF score were observed in TBT rats. MG inflammation was observed in TBT rats. A positive correlation between the MG obesogenic markers and inflammation were observed. High ERα and aromatase expression were observed in MG of TBT rats. MG OS, apoptosis and fibrosis were present in the TBT rats. Additionally, a positive correlation between the MG obesogenic markers and OS were observed in TBT rats. Thus, these data suggest that obesogenic TBT effects led to MG irregularities in the adult female rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Trialquiltina / Enfermedades de la Mama / Glándulas Mamarias Animales Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Trialquiltina / Enfermedades de la Mama / Glándulas Mamarias Animales Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos