Your browser doesn't support javascript.
loading
Relevant effects of Taohong Siwu decoction on isolated rat aortic ring dependent on endothelium nitric oxide-cGMP pathway.
Wu, Qi; Zhao, Wanlong; Chen, Gangling; Su, Xue; Li, Rong.
Afiliación
  • Wu Q; State Key Laboratory of Natural Medicines, Research Department of Pharmacognosy, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Longmian Road, Nanjing, Jiangsu, PR China.
  • Zhao W; Shanghai Qingpu Institute for Food and Drug Control, Shanghai, China.
  • Chen G; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Longmian Road, Nanjing, Jiangsu, PR China.
  • Su X; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Longmian Road, Nanjing, Jiangsu, PR China.
  • Li R; Department of Pharmacology of Chinese Materia Medica, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Longmian Road, Nanjing, Jiangsu, PR China.
Pak J Pharm Sci ; 32(1(Supplementary)): 261-268, 2019 Jan.
Article en En | MEDLINE | ID: mdl-30829202
Using rat thoracic aortic rings to test the relaxing effects of the 95% ethanol extract and aqueous extract of Taohong Siwu decoction (THSW) on endothelium intact or endothelium removed aortic rings. Results showed that the 95% ethanol extract (0.1, 1, 10, 100, 1000 mg•L-1) and aqueous extract (0.1, 1, 10, 100, 1000 mg•L-1) of THSW were able to relax the intact endothelium aortic rings pre-contracted by 10-6 mol•L-1 PE. 10-4 mol•L-1 L-NAME and 10-5 mol•L-1 methylene blue both were able to inhibit the relaxation other than indomethacin. For the endothelium removed aortic rings, potassium channel blocker 3×10-3mol•L-1 tetraethylammonium chloride and 10-5 mol•L-1 glibenclamide had no effect on the relaxation effects caused by the 95% ethanol extract and aqueous extract of THSW. It could be concluded that the 95% ethanol extract and aqueous extract of THSW relax blood vessel by endothelium-dependent way.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Vasodilatadores / Medicamentos Herbarios Chinos / GMP Cíclico / Óxido Nítrico Límite: Animals Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Pakistán
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Vasodilatadores / Medicamentos Herbarios Chinos / GMP Cíclico / Óxido Nítrico Límite: Animals Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Pakistán