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Loss of the Tumor Suppressor HACE1 Contributes to Cancer Progression.
Li, Jun-Chen; Chang, Xing; Chen, Yang; Li, Xin-Zhe; Zhang, Xiang-Lian; Yang, Shi-Ming; Hu, Chang-Jiang; Zhang, Hao.
Afiliación
  • Li JC; Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
  • Chang X; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
  • Chen Y; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
  • Li XZ; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
  • Zhang XL; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
  • Yang SM; Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Guangxi 530021, China.
  • Hu CJ; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
  • Zhang H; Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
Curr Drug Targets ; 20(10): 1018-1028, 2019.
Article en En | MEDLINE | ID: mdl-30827236
HACE1 belongs to the family of HECT domain-containing E3 ligases, which plays an important role in the occurrence, invasion and metastatic process in many human malignancies. HACE1 is a tumor suppressor gene that is reduced in most cancer tissues compared to adjacent normal tissue. The loss or knocking out of HACE1 leads to enhanced tumor growth, invasion, and metastasis; in contrast, the overexpression of HACE1 can inhibit the development of tumors. Hypermethylation reduces the expression of HACE1, thereby promoting tumor development. HACE1 can inhibit the development of inflammation or tumors via the ubiquitination pathway. Therefore, HACE1 may be a potential therapeutic target, providing new strategies for disease prevention and treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Metilación de ADN / Ubiquitina-Proteína Ligasas / Neoplasias Límite: Humans Idioma: En Revista: Curr Drug Targets Asunto de la revista: TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Emiratos Árabes Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Metilación de ADN / Ubiquitina-Proteína Ligasas / Neoplasias Límite: Humans Idioma: En Revista: Curr Drug Targets Asunto de la revista: TERAPIA POR MEDICAMENTOS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Emiratos Árabes Unidos