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The ß- radio-guided surgery: Method to estimate the minimum injectable activity from ex-vivo test.
Russomando, A; Schiariti, M; Bocci, V; Colandrea, M; Collamati, F; Cremonesi, M; Ferrari, M E; Ferroli, P; Ghielmetti, F; Ghisini, R; Grana, C M; Mancini Terracciano, C; Marafini, M; Mirabelli, R; Morganti, S; Papi, S; Patanè, M; Pedroli, G; Pollo, B; Solfaroli Camillocci, E; Traini, G; Faccini, R.
Afiliación
  • Russomando A; Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy; Centro Cientifico Tecnologico de Valparaso-CCTVal, Universidad Tecnica Federico Santa Maria, Chile.
  • Schiariti M; Dip. Neurochirurgia, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
  • Bocci V; INFN Sezione di Roma, Roma, Italy.
  • Colandrea M; Divisione di Medicina Nucleare, Istituto Europeo di Oncologia, Milano, Italy.
  • Collamati F; INFN Sezione di Roma, Roma, Italy; Dip. Scienze di Base e Applicate per l'Ingegneria, Sapienza Univ. di Roma, Roma, Italy.
  • Cremonesi M; Unità Ricerca sulle Radiazioni, Istituto Europeo di Oncologia, Milano, Italy.
  • Ferrari ME; Servizio Fisica Sanitaria, Istituto Europeo di Oncologia, Milano, Italy.
  • Ferroli P; Dip. Neurochirurgia, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
  • Ghielmetti F; Dip. Neurochirurgia, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
  • Ghisini R; Trial Activation and Reporting - Data Management - Clinical Trial Office Direzione Scientifica, Istituto Europeo di Oncologia, Milano, Italy.
  • Grana CM; Divisione di Medicina Nucleare, Istituto Europeo di Oncologia, Milano, Italy.
  • Mancini Terracciano C; INFN Sezione di Roma, Roma, Italy.
  • Marafini M; Museo Storico della Fisica e Centro Studi e Ricerche "E. Fermi", Roma, Italy; INFN Sezione di Roma, Roma, Italy.
  • Mirabelli R; Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy; INFN Sezione di Roma, Roma, Italy.
  • Morganti S; INFN Sezione di Roma, Roma, Italy.
  • Papi S; Unità Produzione Radiofarmaci, Istituto Europeo di Oncologia, Milano, Italy.
  • Patanè M; U.O. Anatomia Patologica, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
  • Pedroli G; Servizio Fisica Sanitaria, Istituto Europeo di Oncologia, Milano, Italy.
  • Pollo B; U.O. Anatomia Patologica, Fondazione Istituto Neurologico Carlo Besta, Milano, Italy.
  • Solfaroli Camillocci E; Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy; INFN Sezione di Roma, Roma, Italy. Electronic address: elena.solfaroli@roma1.infn.it.
  • Traini G; Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy; INFN Sezione di Roma, Roma, Italy.
  • Faccini R; Dip. Fisica, Sapienza Univ. di Roma, Roma, Italy; INFN Sezione di Roma, Roma, Italy.
Phys Med ; 58: 114-120, 2019 Feb.
Article en En | MEDLINE | ID: mdl-30824142
PURPOSE: Radio-guided surgery with ß- decays is a novel technique under investigation. One of the main advantages is its capability to detect small (⩽0.1 ml) samples after injecting the patient with low activity of radiopharmaceutical. This paper presents an experimental method to quantify this feature based on ex-vivo tests on specimens from meningioma patients. METHODS: Patients were enrolled on the basis of the standard uptake value (SUV) and the tumour-to-non-tumour activity ratio (TNR) resulted from 68Ga-DOTATOC PET exams. After injecting the patients with 93-167 MBq of 90Y-DOTATOC, 26 samples excised during surgery were analyzed with a ß- probe. The radioactivity expected on the neoplastic specimens was estimated according to the SUV found in the PET scan and the correlation with the measured counts was studied. The doses to surgeon and medical personnel were also evaluated. RESULTS: Even injecting as low as 1.4 MBq/kg of radiotracer, tumour residuals of 0.1 ml can be detected. A negligible dose to the medical personnel was confirmed. CONCLUSIONS: Radio-guided surgery with ß- decays is a feasible technique with a low radiation dose for both personnel and patient, in particular if the patient is injected with the minimum required activity. A correlation greater than 80% was observed between the measured counts and the expected activity for the lesion samples based on the individual SUV and the TNR. This makes identifiable the minimum injectable radiotracer activity for cases where 90Y is the utilized radionuclide.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioisótopos de Itrio / Partículas beta / Cirugía Asistida por Computador / Tomografía de Emisión de Positrones Límite: Humans Idioma: En Revista: Phys Med Asunto de la revista: BIOFISICA / BIOLOGIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioisótopos de Itrio / Partículas beta / Cirugía Asistida por Computador / Tomografía de Emisión de Positrones Límite: Humans Idioma: En Revista: Phys Med Asunto de la revista: BIOFISICA / BIOLOGIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Italia