Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability.

Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide

Falavigna, Margherita; Klitgaard, Mette; Steene, Erik; Flaten, Gøril Eide.

Afiliación

Falavigna M; Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø The Arctic University of Norway, Universitetsveien 57, 9037 Tromsø, Norway. Electronic address: margherita.falavigna@uit.no.
Klitgaard M; Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø The Arctic University of Norway, Universitetsveien 57, 9037 Tromsø, Norway; Physiological Pharmaceutics, Department of Pharmacy, University of Copenhagen, Universitetsparken 2-4, 2100 Copenhagen, Denmark. Electr
Steene E; Biotec Betaglucans AS, Sykehusvegen 23, 9019 Tromsø, Norway. Electronic address: erik.steene@biotec.no.
Flaten GE; Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø The Arctic University of Norway, Universitetsveien 57, 9037 Tromsø, Norway. Electronic address: goril.flaten@uit.no.

Eur J Pharm Sci ; 132: 44-54, 2019 Apr 30.

Article en En | MEDLINE | ID: mdl-30822502

Asunto(s)

Ayuno/metabolismo; Absorción Intestinal/fisiología; Mucosa Intestinal/metabolismo; Secreciones Intestinales/metabolismo; Intestino Delgado/metabolismo; Modelos Biológicos; Preparaciones Farmacéuticas/metabolismo; Biomimética; Interacciones Alimento-Droga; Humanos; Membranas Artificiales; Permeabilidad; Preparaciones Farmacéuticas/administración & dosificación; Preparaciones Farmacéuticas/química; Farmacocinética; Fosfolípidos/química; Solubilidad

Palabras clave

FaSSIF/FeSSIF; In vitro model; Mucus; Simulated intestinal fluids; pH-dependent permeability; pH-dependent solubility

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Ayuno / Absorción Intestinal / Mucosa Intestinal / Secreciones Intestinales / Intestino Delgado / Modelos Biológicos Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos

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