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FDG-PET in possible cardiac sarcoidosis: Right ventricular uptake and high total cardiac metabolic activity predict cardiovascular events.
Tuominen, Heikki; Haarala, Atte; Tikkakoski, Antti; Kähönen, Mika; Nikus, Kjell; Sipilä, Kalle.
Afiliación
  • Tuominen H; Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, 33520, Tampere, Finland. heikki.tuominen@pshp.fi.
  • Haarala A; Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, 33520, Tampere, Finland.
  • Tikkakoski A; Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, 33520, Tampere, Finland.
  • Kähönen M; Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, 33520, Tampere, Finland.
  • Nikus K; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Sipilä K; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
J Nucl Cardiol ; 28(1): 199-205, 2021 02.
Article en En | MEDLINE | ID: mdl-30815833
BACKGROUND: Cardiac involvement accounts for the majority of morbidity and mortality in sarcoidosis. Pathological myocardial fluorodeoxyglucose (FDG)-uptake in positron emission tomography (PET) has been associated with cardiovascular events and quantitative metabolic parameters have been shown to add prognostic value. Our aim was to study whether the pattern of pathological cardiac FDG-uptake and quantitative parameters are able to predict cardiovascular events in patients with suspected cardiac sarcoidosis (CS). METHODS: 137 FDG-PET examinations performed in Tampere University Hospital were retrospectively analyzed visually and quantitatively. Location of pathological uptake was noted and pathological metabolic volume, average standardized uptake value (SUV), and total cardiac metabolic activity (tCMA) were calculated. Patients were followed for ventricular tachycardia, decrease in left ventricular ejection fraction, and death. RESULTS: Eleven patients had one or more cardiovascular events during the follow-up. Five patients out of 12 with uptake in both ventricles had an event during follow-up. Eight patients had high tCMA (> 900 MBq) and three of them had a cardiovascular event. Right ventricular uptake and tCMA were significantly associated with cardiovascular events during follow-up (P-value .001 and .018, respectively). CONCLUSIONS: High tCMA and right ventricular uptake were significant risk markers for cardiac events among patient with suspected CS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoidosis / Radiofármacos / Fluorodesoxiglucosa F18 / Tomografía de Emisión de Positrones / Ventrículos Cardíacos / Cardiomiopatías Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoidosis / Radiofármacos / Fluorodesoxiglucosa F18 / Tomografía de Emisión de Positrones / Ventrículos Cardíacos / Cardiomiopatías Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos