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Diverse Genome Topologies Characterize Dosage Compensation across Species.
Jordan, William; Rieder, Leila E; Larschan, Erica.
Afiliación
  • Jordan W; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI, USA.
  • Rieder LE; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI, USA; Department of Biology, Emory University, Atlanta, GA, USA.
  • Larschan E; Department of Molecular Biology, Cellular Biology and Biochemistry, Brown University, Providence, RI, USA. Electronic address: erica_larschan@brown.edu.
Trends Genet ; 35(4): 308-315, 2019 04.
Article en En | MEDLINE | ID: mdl-30808531
Dosage compensation is the process by which transcript levels of the X chromosome are equalized with those of autosomes. Although diverse mechanisms of dosage compensation have evolved across species, these mechanisms all involve distinguishing the X chromosome from autosomes. Because one chromosome is singled out from other chromosomes for precise regulation, dosage compensation serves as an important model for understanding how specific cis-elements are identified within the highly compacted 3D genome to co-regulate thousands of genes. Recently, multiple genomic approaches have provided key insights into the mechanisms of dosage compensation, extending what we have learned from classical genetic studies. In the future, newer genomic approaches that require little starting material show great promise to provide an understanding of the heterogeneity of dosage compensation between cells and how it functions in nonmodel organisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Compensación de Dosificación (Genética) / Genoma / Genómica Límite: Animals / Humans Idioma: En Revista: Trends Genet Asunto de la revista: GENETICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Compensación de Dosificación (Genética) / Genoma / Genómica Límite: Animals / Humans Idioma: En Revista: Trends Genet Asunto de la revista: GENETICA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido