Cytotoxic and Antitumor Activity of some Coumarin Derivatives.
Nat Prod Commun
; 11(9): 1289-1292, 2016 Sep.
Article
en En
| MEDLINE
| ID: mdl-30807025
Several natural and synthetic coumarins were assayed against different cancer cell lines. Four of them have shown cytotoxicity against a panel of three human solid tumor cell lines (HeLa, T-47D, and WiDr) and a clearly activity/hydrophobicity relationship. Compound 13 proved to be the most active product in all cell lines tested, with values of 8.0 (±0.38) µM against HeLa cells and also able to inhibit Taq DNA polymerase. This dual activity of 13 makes it a candidate to be considered as a "lead" compound in the search for novel antitumor drugs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cumarinas
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Nat Prod Commun
Asunto de la revista:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Estados Unidos