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Use of ebselen as a neuroprotective agent in rat spinal cord subjected to traumatic injury.
Slusarczyk, Wojciech; Olakowska, Edyta; Larysz-Brysz, Magdalena; Woszczycka-Korczynska, Izabella; de Carrillo, Daria Gendosz; Weglarz, Wladyslaw P; Lewin-Kowalik, Joanna; Marcol, Wieslaw.
Afiliación
  • Slusarczyk W; Department of Physiology, Medical University of Silesia, Katowice, Poland.
  • Olakowska E; Department of Physiology, Medical University of Silesia, Katowice, Poland.
  • Larysz-Brysz M; Department of Physiology, Medical University of Silesia, Katowice, Poland.
  • Woszczycka-Korczynska I; Department of Physiology, Medical University of Silesia, Katowice, Poland.
  • de Carrillo DG; Department of Physiology, Medical University of Silesia, Katowice, Poland.
  • Weglarz WP; Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland.
  • Lewin-Kowalik J; Department of Physiology, Medical University of Silesia, Katowice, Poland.
  • Marcol W; Department of Physiology, Medical University of Silesia, Katowice, Poland.
Neural Regen Res ; 14(7): 1255-1261, 2019 Jul.
Article en En | MEDLINE | ID: mdl-30804257
Spinal cord injury (SCI) causes disturbances of motor skills. Free radicals have been shown to be essential for the development of spinal cord trauma. Despite some progress, until now no effective pharmacological therapies against SCI have been verified. The purpose of our experiment was to investigate the neuroprotective effects of ebselen on experimental SCI. Twenty-two rats subjected to SCI were randomly subjected to SCI with no further treatment (n = 10) or intragastric administration of ebselen (10 mg/kg) immediately and 24 hours after SCI. Behavioral changes were assessed using the Basso, Beattie, and Bresnahan locomotor scale and footprint test during 12 weeks after SCI. Histopathological and immunohistochemical analyses of spinal cords and brains were performed at 12 weeks after SCI. Magnetic resonance imaging analysis of spinal cords was also performed at 12 weeks after SCI. Rats treated with ebselen presented only limited neurobehavioral progress as well as reduced spinal cord injuries compared with the control group, namely length of lesions (cysts/scars) visualized histopathologically in the spinal cord sections was less but cavity area was very similar. The same pattern was found in T2-weighted magnetic resonance images (cavities) and diffusion-weighted images (scars). The number of FluoroGold retrogradely labeled neurons in brain stem and motor cortex was several-fold higher in ebselen-treated rats than in the control group. The findings suggest that ebselen has only limited neuroprotective effects on injured spinal cord. All exprimental procedures were approved by the Local Animal Ethics Committee for Experiments on Animals in Katowice (Katowice, Poland) (approval No. 19/2009).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Aspecto: Ethics Idioma: En Revista: Neural Regen Res Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: India
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Aspecto: Ethics Idioma: En Revista: Neural Regen Res Año: 2019 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: India