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Coronary high-signal-intensity plaques on T1-weighted magnetic resonance imaging reflect intraplaque hemorrhage.
Kuroiwa, Yasuyoshi; Uchida, Akiko; Yamashita, Atsushi; Miyati, Tosiaki; Maekawa, Kazunari; Gi, Toshihiro; Noguchi, Teruo; Yasuda, Satoshi; Imamura, Takuroh; Asada, Yujiro.
Afiliación
  • Kuroiwa Y; Department of Radiological Technology, Koga General Hospital, 1749-4 Sudaki, Ikeuchi, Miyazaki 880-0041, Japan; Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
  • Uchida A; Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
  • Yamashita A; Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. Electronic address: atsushi_yamashita@med.miyazaki-u.ac.jp.
  • Miyati T; Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
  • Maekawa K; Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
  • Gi T; Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
  • Noguchi T; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.
  • Yasuda S; Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565-8565, Japan.
  • Imamura T; Department of Internal Medicine, Koga General Hospital, 1749-4 Sudaki, Ikeuchi, Miyazaki 880-0041, Japan.
  • Asada Y; Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
Cardiovasc Pathol ; 40: 24-31, 2019.
Article en En | MEDLINE | ID: mdl-30797186
Coronary high-signal-intensity plaques (HIPs) detected by T1-weighted magnetic resonance imaging are associated with future cardiovascular events. This study aimed to identify pathological findings reflecting HIPs in coronary arteries obtained from autopsy cases. Formalin-fixed hearts were imaged with noncontrast T1-weighted imaging with a 1.5-T magnetic resonance system. We defined HIPs or non-HIPs as a coronary plaque to myocardial signal intensity ratio (PMR) of ≥1.4 or <1.4, respectively. We found HIPs in 4 of 37 (10.8%) hearts and analyzed 7 hearts in detail. The corresponding sections to HIPs (n=11) or non-HIPs (n=25) were histologically and immunohistochemically analyzed. We calculated the T1 relaxation time of human venous blood in vitro. Plaque and necrotic core areas, and the frequency of intraplaque hemorrhage in HIPs were significantly larger/higher than those in non-HIPs. HIPs were immunopositive for CD68 (11/11), glycophorin A (10/11), and fibrin (11/11). Glycophorin-A-, matrix metalloprotease 9 (MMP9)-, and tissue factor-immunopositive areas were larger in HIPs than in non-HIPs. The PMR was positively correlated with glycophorin-A-, fibrin-, MMP9-, and tissue factor-immunopositive areas. Blood coagulation shortened the T1 relaxation time of the blood and plasma, and the T1 relaxation times in coagulated whole blood and erythrocyte-rich blood were significantly shorter than those in plasma. Coronary HIPs may reflect intraplaque hemorrhage and may be a novel marker for plaque instability and thrombogenic potential.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Imagen por Resonancia Magnética / Vasos Coronarios / Placa Aterosclerótica / Hemorragia Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Cardiovasc Pathol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / PATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Imagen por Resonancia Magnética / Vasos Coronarios / Placa Aterosclerótica / Hemorragia Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Cardiovasc Pathol Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / PATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos