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ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCß3 Catalysis: Targeting It Eradicates Leukemia Stem Cells.
Zhong, Wenbin; Xu, Mengyang; Li, Chanjuan; Zhu, Biying; Cao, Xiuye; Li, Dan; Chen, Huanzhao; Hu, Chunxiu; Li, Rong; Luo, Chengwei; Pan, Guoping; Zhang, Wenqiang; Lai, Chaofeng; Wang, Tong; Du, Xin; Chen, Hong; Xu, Guowang; Olkkonen, Vesa M; Lei, Pingsheng; Xu, Jun; Yan, Daoguang.
Afiliación
  • Zhong W; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Xu M; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Li C; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Zhu B; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Cao X; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Li D; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Chen H; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Hu C; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116011, China.
  • Li R; Department of Hematology, Chang Zheng Hospital, Shanghai 200003, China.
  • Luo C; Department of Hematology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China.
  • Pan G; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Zhang W; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Lai C; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Wang T; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China.
  • Du X; Department of Hematology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510000, China.
  • Chen H; Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Xu G; CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116011, China.
  • Olkkonen VM; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Helsinki 00290, Finland; Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.
  • Lei P; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences, Beijing 100050, China.
  • Xu J; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
  • Yan D; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Department of Biology, Jinan University, Guangzhou 510632, China. Electronic address: tydg@jnu.edu.cn.
Cell Rep ; 26(8): 2166-2177.e9, 2019 02 19.
Article en En | MEDLINE | ID: mdl-30784597
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Células Madre Hematopoyéticas / Leucemia / Receptores de Esteroides / Fosfatidilinositol 4,5-Difosfato Límite: Animals / Humans Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Células Madre Hematopoyéticas / Leucemia / Receptores de Esteroides / Fosfatidilinositol 4,5-Difosfato Límite: Animals / Humans Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos