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Assessing Molecular Epidemiology of Carbapenem-resistant Klebsiella pneumoniae (CR-KP) with MLST and MALDI-TOF in Central China.
Meng, Xiujuan; Yang, Jun; Duan, Juping; Liu, Sidi; Huang, Xun; Wen, Ximao; Huang, Xin; Fu, Chenchao; Li, Jie; Dou, Qingya; Liu, Yao; Wang, Jia; Yan, Qun; Zou, Mingxiang; Liu, Wenen; Peng, Zhong; Chen, Liang; Li, Chunhui; Wu, Anhua.
Afiliación
  • Meng X; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Yang J; Bioyong Technologies Inc, Beijing, China.
  • Duan J; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Liu S; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Huang X; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Wen X; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Huang X; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Fu C; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Li J; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Dou Q; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Liu Y; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.
  • Wang J; Bioyong Technologies Inc, Beijing, China.
  • Yan Q; Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Zou M; Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Liu W; Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
  • Peng Z; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
  • Chen L; Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
  • Li C; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China. lichunhui@csu.edu.cn.
  • Wu A; Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China. xywuanhua@csu.edu.cn.
Sci Rep ; 9(1): 2271, 2019 02 19.
Article en En | MEDLINE | ID: mdl-30783127
Carbapenem-resistant K. pneumoniae (CR-KP) posts significant public health challenge worldwide. The aim of this study is to assess clinical characteristics and molecular epidemiology of CR-KP infections with Multilocus sequence typing (MLST) and Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) in Central China. A total of 71 CR-KP isolates were recovered in a teaching hospital from October 2014 to December 2015. Among all CR-KP isolates, 73.2% (52) produced K. pneumoniae carbapenemases-2 (KPC-2). Eighteen ST types were identified by MLST, among these ST types, forty-seven isolates belonged to ST11 type, which was the predominant outbreak strain in China, and most ST11 isolates produced KPC-2. Eleven mass spectrometry (MS) types were identified by MALDI-TOF MS analysis, 53.5% isolates were MS4 and MS6, which matched with ST11 in MLST analysis. CR-KP infection was associated with increased medical cost and longer hospitalization. Therefore, we found that KPC-2-producing ST11 (MS4 and MS6) CR-KP isolates were the predominant clone identified by MLST and MALDI-TOF, and CR-KP infection was associated with increased hospital costs and longer hospitalization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbapenémicos / Brotes de Enfermedades / Farmacorresistencia Bacteriana / Klebsiella pneumoniae Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbapenémicos / Brotes de Enfermedades / Farmacorresistencia Bacteriana / Klebsiella pneumoniae Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido