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Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia.
Li, Xiao-Qing; Wang, Yang-Yang; Yang, Ting-Ting; Qian, Yi-Ning; Yin, He; Zhong, Shan-Shan; A, Rong; He, Yang; Xu, Bao-Lei; Liu, Guang-Zhi.
Afiliación
  • Li XQ; Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
  • Wang YY; Department of Neurology, Peking University People's Hospital, Beijing, 100044, China.
  • Yang TT; Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
  • Qian YN; Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
  • Yin H; Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
  • Zhong SS; Department of Neurology, Peking University People's Hospital, Beijing, 100044, China.
  • A R; Department of Neurology, Peking University People's Hospital, Beijing, 100044, China.
  • He Y; Department of Neurology, Peking University People's Hospital, Beijing, 100044, China.
  • Xu BL; Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
  • Liu GZ; Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. guangzhi2002@hotmail.com.
Cell Mol Neurobiol ; 39(3): 451-460, 2019 Apr.
Article en En | MEDLINE | ID: mdl-30778712
Various studies demonstrate that CD137 (TNFRSF9, 4-1BB) promotes atherosclerosis and vascular inflammation in experimental models via interactions with the CD137 ligand (CD137L). However, the exact role of CD137 in ischemic stroke remains unclear. In this study, we analyzed dynamic changes of peripheral CD137 expression on T cells in a mouse model of cerebral ischemia-middle cerebral artery occlusion (MCAO), as well as alternation of neurological function, infarct size and cerebral inflammatory status after inhibition of the CD137/CD137L pathway using an anti-CD137L monoclonal antibody. MCAO mice showed elevated surface expression of CD137 on T cells in both peripheral blood and lymphoid tissues during early cerebral ischemia. Remarkably, blockade of the CD137/CD137L pathway reduced the post-ischemic brain damage. Our findings indicate that enhanced CD137 costimulation occurs in early cerebral ischemia and promotes T cell activation, which in turn upregulates inflammatory immune response and possibly exerting deleterious effects on cerebral ischemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isquemia Encefálica / Ligando 4-1BB Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Cell Mol Neurobiol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isquemia Encefálica / Ligando 4-1BB Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Cell Mol Neurobiol Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos