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Retrospective analysis of 659 laryngeal squamous cell carcinoma patients treated with open laryngeal function-preserving operations.
Tang, Di; Tao, Lei; Zhou, Liang; Zhang, Ming; Wu, Haitao; Li, Xiaoming; Chen, Xiaoling; Li, Cai; Xie, Ming; Cheng, Lei.
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  • Tao L; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Zhou L; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Zhang M; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Wu H; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Li X; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Chen X; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Li C; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Xie M; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
  • Cheng L; a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.
Acta Otolaryngol ; 138(11): 1043-1050, 2018 Nov.
Article en En | MEDLINE | ID: mdl-30776268
BACKGROUND: Open laryngeal function-preserving surgery is a common therapeutic strategy for Chinese laryngeal squamous cell carcinoma (LSCC) patients. OBJECTIVES: To explore the fundamental clinical characteristics and survival prognostic factors of LSCC patients treated with open laryngeal function-preserving operations. MATERIAL AND METHODS: about a total of 659 LSCC patients undergoing open laryngeal function-preserving operations were retrospectively reviewed. Kaplan-Meier method, Log-rank test and Cox regression model were performed in survival analyses. RESULTS: About 612 patients were glottic cancer, followed by 44 cases in supraglottis and 3 cases in subglottis. The number of patients in stage T1, T2, T3 and T4 was 190, 365, 100 and 4, respectively. Nineteen patients had positive cervical lymph nodes. The 5-year overall survival, disease-free survival and disease-specific survival rates were 90.1, 84.9 and 90.7%, respectively. T stage and second primary tumour were independent factors predicting overall survival, while T stage and pathological differentiation were independent risk factors for tumour recurrence and progression. CONCLUSIONS AND SIGNIFICANCE: Open laryngeal function-preserving surgery is a crucial therapeutic strategy for Chinese patients with early and, in some cases, advanced-stage LSCC. Early diagnosis and therapy and sufficient and safe surgical margins are key to improving the survival rate and reducing the risk of relapse in LSCC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Laríngeas / Tratamientos Conservadores del Órgano / Laringe Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Acta Otolaryngol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Neoplasias Laríngeas / Tratamientos Conservadores del Órgano / Laringe Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Acta Otolaryngol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido