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Bone mineral density from early to middle adulthood in persons with Down syndrome.
Tang, J Y M; Luo, H; Wong, G H Y; Lau, M M Y; Joe, G M; Tse, M A; Ip, P; Wong, I C K; Lum, T Y S.
Afiliación
  • Tang JYM; Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.
  • Luo H; Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.
  • Wong GHY; Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong.
  • Lau MMY; Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.
  • Joe GM; Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong.
  • Tse MA; Department of Psychiatry, The University of Hong Kong, Hong Kong.
  • Ip P; Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.
  • Wong ICK; Institute of Human Performance, The University of Hong Kong, Hong Kong.
  • Lum TYS; Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong.
J Intellect Disabil Res ; 63(8): 936-946, 2019 08.
Article en En | MEDLINE | ID: mdl-30775821
BACKGROUND: While accelerated ageing is recognised among individuals with Down syndrome (DS), the trajectory of their bone health across adulthood remains poorly understood. METHODS: This study aimed to determine the age-related loss of bone mineral density (BMD) of the lumbar spine in 128 adults with DS aged 18 to 54 years compared with 723 counterparts without DS. RESULTS: Men and women with DS had lower level of BMD than counterparts without DS across age groups. Magnitude of decrement in BMD as reflected in the z-scores was similar between younger and older men with DS. Older women with DS, on the contrary, showed greater decrement in older ages especially in their fourth decade of life. Osteopenia and osteoporosis as defined using age-specific and gender-specific T-scores affected greater number of men with DS (38% and 25%) than women (17% and 17%) aged 40-49 years. CONCLUSIONS: Findings supported adults with DS, especially men, to have early bone mineral testing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Óseas Metabólicas / Densidad Ósea / Síndrome de Down / Envejecimiento Prematuro Tipo de estudio: Etiology_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Intellect Disabil Res Asunto de la revista: TRANSTORNOS MENTAIS Año: 2019 Tipo del documento: Article País de afiliación: Hong Kong Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Óseas Metabólicas / Densidad Ósea / Síndrome de Down / Envejecimiento Prematuro Tipo de estudio: Etiology_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Intellect Disabil Res Asunto de la revista: TRANSTORNOS MENTAIS Año: 2019 Tipo del documento: Article País de afiliación: Hong Kong Pais de publicación: Reino Unido