NPC1L1-Targeted Cholesterol-Grafted Poly(ß-Amino Ester)/pDNA Complexes for Oral Gene Delivery.

Liu, Yuan; Chen, Dan; Li, Jialin; Xia, Dengning; Yu, Miaorong; Tao, Jinsong; Zhang, Xinxin; Li, Li; Gan, Yong

Liu, Yuan; Chen, Dan; Li, Jialin; Xia, Dengning; Yu, Miaorong; Tao, Jinsong; Zhang, Xinxin; Li, Li; Gan, Yong.

Afiliación

Liu Y; Department of Chemistry, Shanghai University, Shanghai, 200444, P. R. China.
Chen D; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai, 201203, P. R. China.
Li J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai, 201203, P. R. China.
Xia D; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai, 201203, P. R. China.
Yu M; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, P. R. China.
Tao J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai, 201203, P. R. China.
Zhang X; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai, 201203, P. R. China.
Li L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai, 201203, P. R. China.
Gan Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 501 Haike Road, Shanghai, 201203, P. R. China.

Adv Healthc Mater ; 8(8): e1800934, 2019 04.

Article en En | MEDLINE | ID: mdl-30773830

Asunto(s)

Colesterol/química; ADN/metabolismo; Proteínas de Transporte de Membrana/metabolismo; Polímeros/química; Transfección/métodos; Administración Oral; Células CACO-2; ADN/genética; Humanos; Luciferasas/genética; Luciferasas/metabolismo; Plásmidos/genética; Plásmidos/metabolismo; Polímeros/metabolismo

Palabras clave

NPC1L1; cellular uptake; cholesterol; oral gene delivery; transfection efficiency

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Polímeros / ADN / Transfección / Colesterol Límite: Humans Idioma: En Revista: Adv Healthc Mater Año: 2019 Tipo del documento: Article Pais de publicación: Alemania

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