Your browser doesn't support javascript.
loading
KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain.
An, Seon Woo A; Choi, Eun-Seok; Hwang, Wooseon; Son, Heehwa G; Yang, Jae-Seong; Seo, Keunhee; Nam, Hyun-Jun; Nguyen, Nhung T H; Kim, Eun Ji E; Suh, Bo Kyoung; Kim, Youngran; Nakano, Shunji; Ryu, Youngjae; Man Ha, Chang; Mori, Ikue; Park, Sang Ki; Yoo, Joo-Yeon; Kim, Sanguk; Lee, Seung-Jae V.
Afiliación
  • An SWA; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Choi ES; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Hwang W; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Son HG; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Yang JS; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Seo K; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Nam HJ; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Nguyen NTH; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Kim EJE; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Suh BK; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Kim Y; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Nakano S; Neuroscience Institute, Graduate School of Science, Nagoya University, Nagoya, Japan.
  • Ryu Y; Research Division Korea Brain Research Institute, Daegu, South Korea.
  • Man Ha C; Research Division Korea Brain Research Institute, Daegu, South Korea.
  • Mori I; Neuroscience Institute, Graduate School of Science, Nagoya University, Nagoya, Japan.
  • Park SK; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Yoo JY; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Kim S; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
  • Lee SV; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, South Korea.
Aging Cell ; 18(3): e12906, 2019 06.
Article en En | MEDLINE | ID: mdl-30773781
PDZ domain-containing proteins (PDZ proteins) act as scaffolds for protein-protein interactions and are crucial for a variety of signal transduction processes. However, the role of PDZ proteins in organismal lifespan and aging remains poorly understood. Here, we demonstrate that KIN-4, a PDZ domain-containing microtubule-associated serine-threonine (MAST) protein kinase, is a key longevity factor acting through binding PTEN phosphatase in Caenorhabditis elegans. Through a targeted genetic screen for PDZ proteins, we find that kin-4 is required for the long lifespan of daf-2/insulin/IGF-1 receptor mutants. We then show that neurons are crucial tissues for the longevity-promoting role of kin-4. We find that the PDZ domain of KIN-4 binds PTEN, a key factor for the longevity of daf-2 mutants. Moreover, the interaction between KIN-4 and PTEN is essential for the extended lifespan of daf-2 mutants. As many aspects of lifespan regulation in C. elegans are evolutionarily conserved, MAST family kinases may regulate aging and/or age-related diseases in mammals through their interaction with PTEN.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Caenorhabditis elegans / Fosfohidrolasa PTEN Límite: Animals Idioma: En Revista: Aging Cell Año: 2019 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Caenorhabditis elegans / Fosfohidrolasa PTEN Límite: Animals Idioma: En Revista: Aging Cell Año: 2019 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido